ID A0A2U3X3V0_ODORO Unreviewed; 2066 AA.
AC A0A2U3X3V0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Multiple PDZ domain protein isoform X2 {ECO:0000313|RefSeq:XP_004416751.1};
GN Name=MPDZ {ECO:0000313|RefSeq:XP_004416751.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004416751.1};
RN [1] {ECO:0000313|RefSeq:XP_004416751.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004202}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004202}.
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DR RefSeq; XP_004416751.1; XM_004416694.1.
DR GeneID; 101383661; -.
DR KEGG; oro:101383661; -.
DR CTD; 8777; -.
DR OrthoDB; 2911488at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 13.
DR Gene3D; 2.30.42.10; -; 13.
DR Gene3D; 1.10.287.650; L27 domain; 1.
DR InterPro; IPR015132; L27_2.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR032078; MPDZ_u10.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR19964; MULTIPLE PDZ DOMAIN PROTEIN; 1.
DR PANTHER; PTHR19964:SF10; MULTIPLE PDZ DOMAIN PROTEIN; 1.
DR Pfam; PF09045; L27_2; 1.
DR Pfam; PF16667; MPDZ_u10; 1.
DR Pfam; PF00595; PDZ; 13.
DR SMART; SM00569; L27; 1.
DR SMART; SM00228; PDZ; 13.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 13.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 13.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 3..63
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 137..224
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 257..337
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 377..463
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 553..634
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 700..775
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1009..1077
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1152..1240
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1351..1434
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1484..1565
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1625..1708
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1721..1803
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1858..1944
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1983..2066
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 466..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1120..1144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1447..1470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1568..1606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1806..1830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1448..1470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1572..1606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1810..1830
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2066 AA; 220740 MW; 3BB2E9439AA620C0 CRC64;
MLETIDKNRA LQAAERLQAK LRERGDVANE DKLNLLKSVL QSPLFGQILN LQTSVQQLKE
QVNTTTLAIS NVEYAHIPHL SPAVIPTLQN ELFLSSSNNG NLEAFTGSGT PHINGKPTCD
EFDQLIKNMA QGRHIEVFEL LKPPCGGLGF SVVGLRSENR GELGIFVQEI QEGSVAHRDG
RLKETDQILA INGQALDQTI THQQAISILQ KAKDNVQLVI ARGSLPQLIS PIVSRSPSAA
STISAHSNPV HWQHVETIEL VNDGSGLGFG IVGGKATGVI VKTILPGGVA DQHGRLCSGD
HILKIGDTDL AGMSSEQVAQ VLRQCGNRVK LMIARGAIEE PAAPSSLGTT LSSSPSCTPE
MRVDASTQKS EESETFDVEL TKNVQGLGIT IAGYIGDKKL EPSGIFVKSI TKSSAVEHDG
RIQIGDQIIA VDGTNLQGFT NQQAVEVLRH TGPTVHLTLM RRGAKQEAEL TSREDVTKDA
VPSPVNASGS KENYEKDEDS SSLSRNTSIL PTEEEGYPLL SAEMEDIEDA QQQEAALLTK
WQRIMGINYE IVVAHVSKFS ENSGLGISLE ATVGHHFIRS VLPEGPVGHS GKLFSGDELL
EVNGITLLGE NHQDVVNILK ELPIEVTMVC CRRTVPPTSQ SGLDSLDLCD IELTEKPHVD
LGEFTGSSET EEPVLAMTEA AQNAEEVQGP LAMWEVDVQH IELEKGNKGL GFSILDYQDP
IDPASTVIVI RSLVPGGIAE KDGRLLPGDR LMFVNDVNLE NSSLEEAVQA LKGAPAGTVR
IGVAKPLPLS PEEGYVSAKE DSFLHPPHSC KEEGLADRAL FRADLALVDT NEANLADEST
LESQYSPDND SICSTQASIL SLHGSACSDG LNYGPSLPSS PPKDVIENSS DPVFDLRLSL
EELYTQNLLQ RQNESPSSVD LSMGPASGFT VNDYTPANAI EQPYKCENTR TWAESHLPNE
MIPSAELTSP MLPDSTGKGS EFLIQQSSLT STAECIMLQN LSKESFERTL TIAKGNSSLG
MTVSANKDGL GMIVRSIIHG GSISRDGRIA VGDCILSINE ESTISLTNAQ ARAMLRRHSL
IGPDIKITYV PAEHLEEFKI SLGQQSGGIM ALDIFSSSSG RDIPELPERE EGEGEESELQ
NSAYSNWNQP RRVELWREPS KSLGISIVGG RGMGSRLSNG EVMRGIFIKH VLEDSPAGKN
GTLKPGDRIV EVDGMDLRDA SHEQAVEAIR KAGNPVVFMV QSIINRPRKS PLPSLPHNLY
PKYNFSSTNP FADSLQFNAD KAPSQSESEP EKAPLCSAPL LPSSAFAEMS GDHTQLSASK
ITEDVDEGDE FGYSWKNIRE RYGTLTGELH MIELEKGRSG LGLSLAGNKD RSRMSVFVVG
IDPNGAAGKD GRLQIADELL EINGQILYGR SHQNASSIIK CAPSKVKIIF IRNKDAVSQM
AVCPGNTVEP LPSTSENSQN KEAEPSGTTS DAAVDLCSFK NVQHLELPKD QGGLGIAISE
EDTLSGVVIK SLTEHGVAAK DGRLKVGDQI LAIDDEVVVG YPVEKFISLL KTAKTTVKLS
IHAENRDPLA GTANGEQKSS SLSPTAPSSG SPEPESLPST SRSSTPAIFA SDPATCPIIP
GCETTIEISK GRTGLGLSIV GGSDTLLGAI IIHEVYEEGA ACKDGRLWAG DQILEVNGID
LRKATHDEAI HVLRQTPPRV RLTLYRDEAP YKEEDVYDTL TVELQKKPGK GLGLSIVGKR
NDTGVFVSDI VKGGIADADG RLVQGDQILT VNAEDVRHAT QEAVAALLKC SLGTVTLEVG
RIKAGPFHSE RRPSQSSQMS EGSLSSFTFP LSGSSTSESL ESSLKKNALA SEIQGLRTVE
IKKGPTDSLG ISIAGGVGSP LGDVPIFIAM MHPNGVAAQT QKLRVGDRIV TICGTSTEGM
THTQAVNLLK NASGSIEMQV VAGGDVSVVT GHQQEPATSS LSFTGLTSSS IFQDDLGPPQ
CKSITLDRGP DGLGFSIVGG YGSPHGDLPI YVKTVFAKGA ASEDGRLKRG DQIIAVNGQS
LEGVTHEEAV AILKRTKGTV TLMVLS
//
