ID   A0A2U3X5X0_ODORO        Unreviewed;       514 AA.
AC   A0A2U3X5X0;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Gap junction protein {ECO:0000256|RuleBase:RU000630};
GN   Name=GJA9 {ECO:0000313|RefSeq:XP_004417838.1};
OS   Odobenus rosmarus divergens (Pacific walrus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC   Odobenus.
OX   NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004417838.1};
RN   [1] {ECO:0000313|RefSeq:XP_004417838.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell.
CC       {ECO:0000256|RuleBase:RU000630}.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC       {ECO:0000256|RuleBase:RU000630}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, gap junction
CC       {ECO:0000256|ARBA:ARBA00004610}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004651,
CC       ECO:0000256|RuleBase:RU000630}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the connexin family.
CC       {ECO:0000256|RuleBase:RU000630}.
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DR   RefSeq; XP_004417838.1; XM_004417781.1.
DR   STRING; 9708.A0A2U3X5X0; -.
DR   GeneID; 101369737; -.
DR   KEGG; oro:101369737; -.
DR   CTD; 81025; -.
DR   InParanoid; A0A2U3X5X0; -.
DR   OrthoDB; 5301774at2759; -.
DR   Proteomes; UP000245340; Unplaced.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0007154; P:cell communication; IEA:InterPro.
DR   Gene3D; 1.20.1440.80; Gap junction channel protein cysteine-rich domain; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; CONNEXIN; 1.
DR   PANTHER; PTHR11984:SF60; GAP JUNCTION ALPHA-9 PROTEIN; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Gap junction {ECO:0000256|ARBA:ARBA00022868,
KW   ECO:0000256|RuleBase:RU000630};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000630};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        78..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        210..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          43..76
FT                   /note="Connexin N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00037"
FT   DOMAIN          167..233
FT                   /note="Gap junction protein cysteine-rich"
FT                   /evidence="ECO:0000259|SMART:SM01089"
SQ   SEQUENCE   514 AA;  58554 MW;  3640C2DFBC9FCB3A CRC64;
     MGNWNFLGGI PEEVHIHSTI IGKIWLTILF IFRMLVLGVA AEDVWNDEQS SFICNTEQPG
     CRNVCYDQAF PISLIRYWVL QVIFVSSPSL VYIGHALYRL RVLEKERQRR KAQLRGALEG
     VEFEIPGDRR RLQQELCQLE QRKLNKAPLR GTLLCTYVVH IFTRSVVEVG FMIGQYLLYG
     FHLEPLVKCH GHPCPNIIDC FVSRPTEKTI FLLFMQSIAT VSLFLNVLEI FHLGFKKIKR
     GLWGQYKWKD EHNEFFANKS KQNHARYQST SANSLKRLSS APDYYLLMEK QKHTAVCPIL
     NSPAFQADPD NHNGNDEKCI LDEXETVLSD EMWTRSATCS HLQHISSYNN EDTHKIFRKE
     VGSPLREKRE IDGKDSKRNH CSRCHCSIPG VAIDLDNHMG QSSQTAFAPP ANCAWEQLWL
     RSTCCPSMED ENQVSPPKGN VKGQFREGTI STLPPLLGNC QPLHIPDTPD SLGQLSFESD
     LARICNNPAA CPPNHLVLLT NNLTGRRTPT DLQI
//