ID A0A2U3X729_LEPWE Unreviewed; 1223 AA.
AC A0A2U3X729;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Protein transport protein Sec24B isoform X3 {ECO:0000313|RefSeq:XP_006727256.1};
GN Name=SEC24B {ECO:0000313|RefSeq:XP_006727256.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006727256.1};
RN [1] {ECO:0000313|RefSeq:XP_006727256.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006727256.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_006727256.1; XM_006727193.2.
DR AlphaFoldDB; A0A2U3X729; -.
DR GeneID; 102740227; -.
DR CTD; 10427; -.
DR OrthoDB; 977017at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR13803:SF42; PROTEIN TRANSPORT PROTEIN SEC24B; 1.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 557..593
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 630..869
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 874..958
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 969..1069
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 1096..1169
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..407
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1223 AA; 132764 MW; 15AD7827720A98E4 CRC64;
MSVPAESPHP AASARIPPKL GGATASGAAA PAGPGPAPHQ QNGPAQSQMQ VPSGYGVHPQ
NYIPPSGHYP QGPGKMTSLP LDSQCDYYSG LYTVPTQNVV TPNTANQQPG AQHMYGRGPP
APHIVGSTPG SFQGAASSTS HLHTSASQPY SPFVNHYSSP AMYSANSSVA SQGFPSTCGH
YAMSTVSNAA YPSVSYPSLP AGDPYGQQVF TSQNAPTVRP VRDNSFSGHS TAIGHPSPLP
PPPSHQYHQQ QSLSGCSTLS WSTSGLPSTQ DNLVRNHTGT LATASSNPTN TVADSLSRPV
MQNVQPLKSS PVVSTVLSGA SSTRTPAAAN RPIEPVASVT QPSELLQQKG VDSSSTTSSA
SPVPNSYDAL EGGSYPDMLS SSASSPAPDP APEPDPAPAP APSAPQPSKM AKPFGYGYPA
LQPGYQNATA PLNSTVPPSS PGYSGFQPYA QQYPGMNQLS SSLGGLSLQS SPQPESLRPV
NLTQERNILP MTPVWAPVPN LNLDLKKLNC SPDSFRCTLT NIPQTQALLN KAKLPLGLLL
HPFRDLTQLP VITSNTIVRC RSCRTYINPF VSFIDQRRWK CNLCYRVNDV PEEFMYNPLT
RSYGEPHKRP EVQNSTVEFI ASSDYMLRPP QPAVYLFVLD VSHNAVEAGY LTILCQSLLE
NLDKLPGDSR TRIGFMTFDS TIHFYNLQEG LSQPQMLIVS DIDDVFLPTP DSLLVNLYES
KELIKDLLNA LPNMFTNTRE THSALGPALQ AAFKLMSPTG GRVSVFQTQL PSLGAGLLQS
REDPNQRSST KVVQHLGPAT DFYKKLALDC SGQQTAVDLF LLSSQYSDLA SLACMSKYSA
GCIYYYPSFH YTHNPSQAEK LQKDLKRYLT RKIGFEAVMR IRCTKGLSMH TFHGNFFVRS
TDLLSLANIN PDAGFAVQLS IEENLTDTSL VCFQTALLYT SSKGERRIRV HTLCLPVVSS
LADVYAGVDV QAAVCLLANM AVDRSISSSL SDARDALVNA VVDSLSAYGS TVSDLQHSAL
IAPSSLKLFP LYVLALLKQK AFRTGTSTRL DDRVYAMCQI KCQPLVHLMK MIHPNLYRID
RLTDEGAIHV NDRVVPQPPL QKLSAEKLTR EGAFLMDCGS VFYIWIGKSC DNNFIEDVLG
YPNFASIPQK MTHLPELDTL SSERARSFIT WLRDNRPLSP VLHVVKDESP AKTEFFQHLI
EDRTEAAFSY YEFLLHIQQQ ICK
//
