ID A0A2U3X9H3_LEPWE Unreviewed; 729 AA.
AC A0A2U3X9H3;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=ADP-ribosylation factor-binding protein GGA3 {ECO:0000313|RefSeq:XP_006728125.1};
GN Name=GGA3 {ECO:0000313|RefSeq:XP_006728125.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006728125.1};
RN [1] {ECO:0000313|RefSeq:XP_006728125.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006728125.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004150}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GGA protein family.
CC {ECO:0000256|ARBA:ARBA00008099}.
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DR RefSeq; XP_006728125.1; XM_006728062.2.
DR AlphaFoldDB; A0A2U3X9H3; -.
DR STRING; 9713.A0A2U3X9H3; -.
DR GeneID; 102729888; -.
DR KEGG; lww:102729888; -.
DR CTD; 23163; -.
DR OrthoDB; 2917368at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd14240; GAT_GGA3; 1.
DR CDD; cd17008; VHS_GGA3; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.60.40.1230; -; 1.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR008153; GAE_dom.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR044111; GAT_GGA3.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR027422; GGA1-3.
DR InterPro; IPR041198; GGA_N-GAT.
DR InterPro; IPR002014; VHS_dom.
DR InterPro; IPR046996; VHS_GGA3.
DR PANTHER; PTHR45905:SF3; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA3; 1.
DR PANTHER; PTHR45905; GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF18308; GGA_N-GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50180; GAE; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 16..146
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 171..298
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT DOMAIN 600..721
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
FT REGION 333..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 201..238
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 346..363
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 729 AA; 78804 MW; 051826284AEDD0E0 CRC64;
MAEAEGESLE SWLNKATNPS NRQEDWEYII GFCDQINKEL EGPQIAVRLL AHKIQSPQEW
EAVQALTVLE ACMKNCGRRF HNEVGKFRFL NELIKVVSPK YLGDRVSEKV KTKVIELLYS
WTLALPEETK IKDAYHMLKR QGIVQSDPLI PVDRTLIPSP PPRPKNPVFD DEEKSKLLAK
LLKSKNPDDL QEANKLIKSM VKEDEARIQK VTKRLHTLEE VNNNVKLLNE MLLHYSKEDS
SEADKELMKE LFDRCESKRR TLFKLASETE DNDNSLGDIL QASDNLSRVI NSYRTIVEGQ
VINGEVATSA MPDAEGNRSR NQGTLIDLAE LDTPSSSSSV LAPAPAPPSS GIPILPPPPQ
TSGPGRSHSS SQAEAPPGPS STSNALCLLD EELLCLGLTD PAPTAPPRES AANSQWPLFQ
NEQSDLDFCS PKPGSAACSP SDGPLVPPSA PSAGSSQAPL PSPFPAPVVP ASVPAPKAGS
FLFPTGLAPA PKAESTALGY HGSALGDSTL HQLDALDHLL EETRVTSGLV KPVSSIFFPG
ATTSPLIPTS TTARPLLPFS PGPGSPLFQP PAFQSQGSPM KGPELSLASV HVPLESIKPS
SALPVTAYDK NGFRILFHFA KECPPGRPDV LVVVVSMLNT APLPVKSIVL QAAVPKSMKV
KLQPPSGTEL SPFSPVQPPA AITQVMLLAN PLKEKARLRY RLTFALGEQL STEVGEVDQF
PPVEQWGNL
//
