ID A0A2U3XDT3_LEPWE Unreviewed; 612 AA.
AC A0A2U3XDT3;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=T-box transcription factor TBX18 {ECO:0000313|RefSeq:XP_006729488.1};
GN Name=TBX18 {ECO:0000313|RefSeq:XP_006729488.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006729488.1};
RN [1] {ECO:0000313|RefSeq:XP_006729488.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006729488.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR RefSeq; XP_006729488.1; XM_006729425.2.
DR AlphaFoldDB; A0A2U3XDT3; -.
DR STRING; 9713.A0A2U3XDT3; -.
DR GeneID; 102742749; -.
DR KEGG; lww:102742749; -.
DR CTD; 9096; -.
DR OrthoDB; 5323209at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20191; T-box_TBX15_18_22-like; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR PANTHER; PTHR11267:SF20; T-BOX TRANSCRIPTION FACTOR TBX18; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 148..335
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT REGION 32..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 612 AA; 65199 MW; 5F6B9D8DE8AF63CF CRC64;
MAEKRRGSPC SMLSLKAHAF SVEALIGAEK QQQLQKKRRK LGAEEAAGAV DDGGCSRGAG
AGEKGSPEGD EGAALPPPAG AASGPGRSCA DLERSCGSRG AAGGCEDGFL QGASPLASPG
GSPKGSPAPS LARPGTPLPS PQAPRVDLQG AELWKRFHEI GTEMIITKAG RRMFPAMRVK
ISGLDPHQQY YIAMDIVPVD NKRYRYVYHS SKWMVAGNAD SPVPPRVYIH PDSPASGETW
MRQVISFDKL KLTNNELDDQ GHIILHSMHK YQPRVHVIRK DCGDDLSPIK PVPSGEGVKA
FSFPETVFTT VTAYQNQQIT RLKIDRNPFA KGFRDSGRNR MGLEALVESY AFWRPSLRTL
TFEDIPGIPK QGNTSSSTLL QGSGNGVPAT HPHLLSGSPC SSPAFHLGPN TSQLCSLAPA
DYSTCARSGL TLNRYSTSLA ETYNRLTNQP GETFAAPRTP SYVGVSSSTS VNMSLGGTDG
DTFSCPQTSL SMQISGMSPQ LQYIMPSPSS NAFAANQTHQ GSYNTFRLHS PCALYGYNFS
TSPKLAASPE KIVSSQGSFL GSSPSGTMTD RQMLPPVEGV HLLSSGGQQS FFDSRTLGSL
PLSSSQVSAH MV
//
