ID A0A2U3XEV4_LEPWE Unreviewed; 2491 AA.
AC A0A2U3XEV4;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Ankyrin repeat domain-containing protein 17 isoform X1 {ECO:0000313|RefSeq:XP_006729868.1};
GN Name=ANKRD17 {ECO:0000313|RefSeq:XP_006729868.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006729868.1};
RN [1] {ECO:0000313|RefSeq:XP_006729868.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006729868.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_006729868.1; XM_006729805.2.
DR STRING; 9713.A0A2U3XEV4; -.
DR GeneID; 102736231; -.
DR KEGG; lww:102736231; -.
DR CTD; 26057; -.
DR OrthoDB; 5480610at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd22502; KH-I_ANKRD17; 1.
DR CDD; cd22249; UDM1_RNF168_RNF169-like; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 9.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047375; KH-I_ANKRD17.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR PANTHER; PTHR23206:SF1; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 17; 1.
DR PANTHER; PTHR23206; MASK PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 8.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00013; KH_1; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 25.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 20.
DR PROSITE; PS50088; ANK_REPEAT; 20.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT REPEAT 187..219
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 220..252
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 253..285
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 287..319
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 320..352
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 353..385
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 386..418
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 450..482
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 483..515
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 516..548
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 550..582
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 969..1001
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1002..1034
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1036..1068
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1069..1101
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1104..1136
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1138..1170
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1171..1203
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1206..1238
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1239..1271
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1611..1681
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT REGION 1366..1557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1571..1604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1793..1882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1898..2033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2051..2082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2161..2224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2266..2335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 695..791
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1380..1416
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1419..1454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1483..1542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1571..1594
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1831..1882
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1898..1916
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1934..2001
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2002..2023
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2161..2189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2266..2289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2321..2335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2491 AA; 263718 MW; 683B48A3AAFF677E CRC64;
MVETAAEMEA YVLEDILEVE SFILDQDDLE NPMLETASKL LLSGTADGAD LRTVDPETQA
RLEALLEAAG IGKLSTADGK AFADPEVLRR LTSSVSCALD EAAAALTRMR AESTANAGQS
DNRSLAEACS EGDVNAVRKL LIEGRSVNEH TEEGESLLCL ACSAGYYELA QVLLAMHANV
EDRGIKGDIT PLMAAANGGH VKIVKLLLAH KADVNAQSST GNTALTYACA GGYVDVVKVL
LESGASIEDH NENGHTPLME AGSAGHVEVA RLLLENGAGI NTHSNEFKES ALTLACYKGH
LEMVRFLLEA GADQEHKTDE MHTALMEACM DGHVEVARLL LDSGAQVNMP ADSFESPLTL
AACGGHVELA ALLIERGASL EEVNDEGYTP LMEAAREGHE EMVALLLGQG ANINAQTEET
QETALTLACC GGFLEVADFL IKAGADIELG CSTPLMEAAQ EGHLELVKYL LAAGANVHAT
TATGDTALTY ACENGHTDVA DVLLQAGADL EHESEGGRTP LMKAARAGHV CTVQFLISKG
ANVNRTTANN DHTVLSLACA GGHLAVVELL LAHGADPTHR LKDGSTMLIE AAKGGHTSVV
CYLLDYPNNL LSAPPPDVTQ LTPPSHDLNR APRVPVQALP MVVPPQEPDK PPANIATTLP
IRNKAASKQK SSSHLPANSQ DVQGYITNQS PESIVEEAQG KLTELEQRIK EAIEKNAQLQ
SLELAHADQL TKEKIEELNK TREEQIQKKQ KILEELQKVE RELQLKTQQQ LKKQYLEVKA
QRIQLQQQQQ QSCQHLGLLT PVGVGEQLSE GDYARLQQVD PVLLKDEPQQ TAAQMGFAPI
QPLAMPQALP LAAGPLPPGS IANLTELQGV IVGQPVLGQA QLAGLGQGIL TETQQGLMVA
SPAQTLNDTL DDIMAAVSGR ASAMSNTPTH SIAASISQPQ TPTPSPIISP SAMLPIYPAI
DIDAQTESNH DTALTLACAG GHEELVQTLL ERGASIEHRD KKGFTPLILA ATAGHVGVVE
ILLDNGADIE AQSERTKDTP LSLACSGGRQ EVVELLLARG ANKEHRNVSD YTPLSLAASG
GYVNIIKILL NAGAEINSRT GSKLGISPLM LAAMNGHTAA VKLLLDMGSD INAQIETNRN
TALTLACFQG RTEVVSLLLD RKANVEHRAK TGLTPLMEAA SGGYAEVGRV LLDKGADVNA
PPVPSSRDTA LTIAADKGHY KFCELLIGRG AHIDVRNKKG NTPLWLAANG GHLDVVQLLV
QAGADVDAAD NRKITPLMAA FRKGHVKVVR YLVKEVNQFP SDSECMRYIA TITDKEMLKK
CHLCMESIVQ AKDRQAAEAN KNASILLEEL DLEKLREESR RLALAAKREK RKEKRRKKKE
EQRRKLEEIE AKNKENFELQ AAQEKEKHKV EDEPEVLTEP PSATTTTTIG ISATWTTLAG
SHGKRNNTIT TTSSKRKNRK NKITPENVQI IFDDPLPISY SQPEKVNGES KSSSTSESGD
SDNMRISSCS DESSNSNSSR KSDNHSPAVV TTTMTSKKQP SVLVTFPKEE RKSVSGKASI
KLSETINEVT SNSLSTCTKS GPSPLSSPNG KLTVASPKRG QKREEGWKEV VRRSKKVSVP
STVISRVIGR GGCNINAIRE FTGAHIDIDK QKDKTGDRII TIRGGTESTR QATQLINALI
KDPDKEIDEL IPKNRLKSSS ANSKIGSSAP TTTAANSSLM GIKMTTVALS STSQTATALT
VPAISSASTH KTIKNPVNNV RPGFPVSLPL AYPPPQFAHA LLAAQTFQQI RPPRLPMTHF
GGTFPPAQST WGPFPVRPLS PARATNSPKP HMVPRHSNQN SSGSQVNSAG SLTSSPTTTT
SSSASTVPGT STNGSPSSPS VRRQLFVTVV KTSNATTTTV TTTASNNSTA PTNATYPMPT
AKEHYPVSSP SSPSPPAQSG GVSRNSPLDC GTASPNKGAS SSEQEAGSPP VVETTNSRLS
NSSSSSGSSS VHSAQQQPPG SVSQEPRPPL QPSQVPPPEV RMTVPPLATT SSAPVAVPST
APVTYPMPQT QMGCSQPAPK METPAVRPPS HGTTAPHKNP APVQNSSVAV LSVNHIKRPH
SVPSSVQLPS TLSTQSACQN SVHPANKPIA PNFSAPLPFG PFSTLFENSP TSAHAFWGGS
VVSSQSTPES MLSGKSSYLP NSDPLHQSDT SKAPGFRPPL QRPAPSPSGI VNMDSPYGSV
TPSSTHLGNF ASNLSGGQMY GPGAPLGGAP TAANFNRQHF SPLSLLTPCS SASNDSPAQS
VSSGVRAPSP APSSVPLGSE KPSNVSQDRK VPVPIGTERS ARIRQTGTSA PSVIGSNLST
SVGHSGIWSF EGIGGNQDKV DWCNPGMGNP MIHRPMSDPG VFSQHQAMER ESTGIVTPSG
TFHQHVPAGY MDFPKVGGMP FSVYGNAMIP PVAPIPDGAG GPIFNGPHAA DPSWNSLIKM
VSSSTENNGP QTVWTGPWAP HMNSVHMNQL G
//
