ID A0A2U3XF67_LEPWE Unreviewed; 1545 AA.
AC A0A2U3XF67;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Nuclear factor of activated T-cells 5 isoform X1 {ECO:0000313|RefSeq:XP_006730125.1};
GN Name=NFAT5 {ECO:0000313|RefSeq:XP_006730125.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006730125.1};
RN [1] {ECO:0000313|RefSeq:XP_006730125.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006730125.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_006730125.1; XM_006730062.2.
DR STRING; 9713.A0A2U3XF67; -.
DR GeneID; 102749623; -.
DR KEGG; lww:102749623; -.
DR CTD; 10725; -.
DR OrthoDB; 5405363at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd01178; IPT_NFAT; 1.
DR CDD; cd07882; RHD-n_TonEBP; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR015646; NFAT5_RHD_DNA-bd.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF10; NUCLEAR FACTOR OF ACTIVATED T-CELLS 5; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Transcription {ECO:0000256|ARBA:ARBA00023015};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 282..461
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 58..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 882..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1215..1248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1262..1281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1289..1315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1334..1385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..908
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1545 AA; 166978 MW; 93C10F4CC280B91D CRC64;
MPSDFISLLS ADLDLESPKS LYSRDSLKLH PSQNFHRAGL LEESVYDLLP KELQLPPSRE
TSVASMSQTS GGEAGSPPPA VVAADASSAP SSSSMGGACS SFTTSSSPTI YSTSVTDSKA
MQVESCSSAL GVSNRGVSEK QLTSNTVQQH PSTPKRHTVL YISPPPEDLL DNSRMSCQDE
GCGLESEQSC SMWMEDSPSN FSNMSTSSYN DNTEVPRKSR KRNPKQRPGV KRRDCEESNM
DIFDADSAKA PHYVLSQLTT DNKGNSKAGN GTLENQKGSG VKKSPMLCGQ YPVKSEGKEL
KIVVQPETQH RARYLTEGSR GSVKDRTQQG FPTVKLEGHN EPVVLQVFVG NDSGRVKPHG
FYQACRVTGR NTTPCKEVDI EGTTVIEVGL DPSNNMTLAV DCVGILKLRN ADVEARIGIA
GSKKKSTRAR LVFRVNITRK DGSTLTLQTP SSPILCTQPA GVPEILKKSL HSCSVKGEEE
VFLIGKNFLK GTKVIFQENV SDENSWKSEA EIDMELFHQN HLIVKVPPYH DQHITLPVSV
GIYVVTNAGR SHDVQPFTYT PDPAAAGALN VNVKKEISSP SRPCSFEEAM KAMKTTGCNL
DKVNILPNAL ITPLISSSMI KSEDVTPMEV TAEKRSSPIF KTAKTVGSTQ QTLENISNMA
GNGSFSSSSS SHLPSENEKQ QQIQPKTYNP ETLTTIQTQD ISQPGTFPAV SASSQLPSSE
ALLQQAPQFQ TRETQSRDVL QSDGTVVNLS HLTESSQQQQ QSPLQEQAQT LQQQISSNIF
PSPNSVSQLQ NTIQHLQAGS FTGSTASGSS GNVDLVQQVL EAQQQLSSVL FSAPDGNENV
QEQLSADIFQ QVSQIQNSVS PGMFSSTEPA VHTRPDNLIA GRAESVHPPP ENTLSGQQQQ
QQQQQVMESS AAMVMEMQQS ICQAAAQIQS ELFPSPASAN GNLQQSPVYQ QTSHMMSALS
TNEDMQMQCE LFSSPPAVSG NETTTTTTQQ VATPGTTMFQ TSSSADGEET GAQAKQIQNS
VFQTMVQMQH SGDSQAQVNL FSSTKSMMSV QSNGTQQQGN GLFQQGNEMM SLQSGNFLQQ
SSHSQAPLFH PPNPIADAQN LSQDAQGSIF HSPSPIVHSQ TSTTSSEQMQ PPMFHSQSTM
AVLQGSSVPQ DQQSANLFLS QSPMNNLQSN TVAQEEQISF FAAQNSISPL QSTSNTEQQA
AFQQQAPISH IQTPMLSQEQ AQPSQQGMFQ PQVSLGSLPP NPMPQNQQGT IFQAPRSIVT
LQSNSPSQEQ QQQQQQQQQQ SILFSSQNTM ATMASQKQPP PNMMFSPGQN PMANQEQQNQ
AIFHQQNNMA PMNQEQQPMQ FQNQPTVSSL QNPGPAQSES PQTSLFHSSP QIQLVQGSPS
SQEQQVTLFL SPASMSALQT SMNQQDMQQS PLYSPQNNMP GIQGAASSPQ AQATLFHNTT
GGTMNQLQNS PGSSQQTSGM FLFGIQNNCS QLLTSGPATL PDQLMAISQP GQPQNEGQPP
VTTLLSQQMP ENSSLASSIN ANQNIEKIDL LVSLQNQGNN LTGTF
//