ID A0A2U3XF88_LEPWE Unreviewed; 1075 AA.
AC A0A2U3XF88;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 {ECO:0000313|RefSeq:XP_006730147.1};
GN Name=NFATC3 {ECO:0000313|RefSeq:XP_006730147.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006730147.1};
RN [1] {ECO:0000313|RefSeq:XP_006730147.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006730147.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_006730147.1; XM_006730084.2.
DR AlphaFoldDB; A0A2U3XF88; -.
DR STRING; 9713.A0A2U3XF88; -.
DR GeneID; 102730825; -.
DR KEGG; lww:102730825; -.
DR CTD; 4775; -.
DR OrthoDB; 5405363at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd01178; IPT_NFAT; 1.
DR CDD; cd07881; RHD-n_NFAT; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF6; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000245341}.
FT DOMAIN 415..596
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 17..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 887..987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1044..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 887..943
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..987
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1075 AA; 115766 MW; 69669F93BEADB0BE CRC64;
MTTANCGAHD ELDFKLVFGE DGAPAPPPSG SRPADLEPDD CASIYIFNVD PPPSTLNSPL
CLPHHGLPSH SSVLSPSFQL QGHKNYEGTC EIPESKYSPL GGPKTFECPS IQITSISPNC
HQEIDAHEDD LHINDPEREY LERPSRDHLY LPLEPSYRES SLSPSPASSI SSRSWFSDAS
SCESLSHIYD DVDSELNEAA ARFTLGSPLT SPGGSPGGCP GEESWHQQYG LGHSLSPRQS
PCHSPRSSVT DENWLSPRPA SGPSSRPTSP CGKRRHSSAE VCYAGSLSPH HSPVPSPGHS
PRGSVTEDTW LNASVQGGSG LGPALFPFQY CVETDIPLKT RKTSEDQATV LPGKLELCSD
DQGNLSPSRE TSIDDGLGSQ YPLKKDSSGD QFLSVPSPFT WSKPKPGHTP IFRTSSLPPL
DWPLPTHFGQ CELKIEVQPK THHRAHYETE GSRGAVKAST GGHPVVKLLG YSEKPINLQM
FIGTADDRYL RPHAFYQVHR ITGKTVATAS QEIIIASTKV LEIPLLPENN MSASIDCAGI
LKLRNSDIEL RKGETDIGRK NTRVRLVFRV HIPQPNGKVL SLQTASIPVE CSQRSAQELP
HIEKYSINSC SVNGGHEMVV TGSNFLPESK IIFLEKGQDG RPQWEVEGKI IREKCQGAHI
VLEVPPYHNP AVTAAVQVHF YLCNGKRKKS QSQRFTYTPV LMKQEHKEEV DLSTVPALSV
PHPAQTQRPS SDTGHPHDSV LSTQRSLVCP IQQTYASMVT SSHLPQLQCR DESAGKEQHM
ISSSVMHQPF QVTSTPPVGS SYQPMQTNIV YNGPTCLPVN AASSQDFDPV LFPQDAALPS
LINLGCQPPS SIPFHSSNSS PTGHLLAHTS HSVQTLPHLQ SMGFHCANTG QRSLSSPGAD
QVTGQPSPQL QPITYGPSHS GSATTTSPAV SHTLASSPLS GPPSPQLQSM PYQSPSSGTA
SSLSLATRMH SGQHTTQAQN TGQGGLSAPS SLICHNLCDP ASFPPDEATV NIKPEPEEQE
PNFSTIGLQD ITLDDVNEII GRDMSQISVS QGTGASRQAP LPGPDSLDIG RSDGL
//
