ID A0A2U3XG67_LEPWE Unreviewed; 2803 AA.
AC A0A2U3XG67;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Nipped-B protein {ECO:0000256|RuleBase:RU364107};
GN Name=NIPBL {ECO:0000313|RefSeq:XP_006730477.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006730477.1};
RN [1] {ECO:0000313|RefSeq:XP_006730477.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006730477.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364107}.
CC -!- SIMILARITY: Belongs to the SCC2/Nipped-B family.
CC {ECO:0000256|ARBA:ARBA00009252, ECO:0000256|RuleBase:RU364107}.
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DR RefSeq; XP_006730477.1; XM_006730414.1.
DR STRING; 9713.A0A2U3XG67; -.
DR GeneID; 102739762; -.
DR KEGG; lww:102739762; -.
DR CTD; 25836; -.
DR OrthoDB; 1409889at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0009790; P:embryo development; IEA:UniProt.
DR GO; GO:0061780; P:mitotic cohesin loading; IEA:InterPro.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026003; Cohesin_HEAT.
DR InterPro; IPR024986; Nipped-B_C.
DR InterPro; IPR033031; Scc2/Nipped-B.
DR PANTHER; PTHR21704:SF18; NIPPED-B-LIKE PROTEIN; 1.
DR PANTHER; PTHR21704; NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED; 1.
DR Pfam; PF12765; Cohesin_HEAT; 1.
DR Pfam; PF12830; Nipped-B_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU364107};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364107};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364107}.
FT DOMAIN 2274..2454
FT /note="Sister chromatid cohesion C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12830"
FT REGION 128..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..945
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1016..1046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1059..1190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2472..2519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2650..2695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..342
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..510
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..935
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1030..1044
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1066..1089
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1097..1142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2675..2692
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2803 AA; 316042 MW; BC1D2DACC4DC73F3 CRC64;
MNGDMPHVPI TTLAGIASLT DLLNQLPLPS PLPATTTKSL LFNARIAEEV NCLLACRDDN
LVSQLVHSLN QVSTDHIELK DNLGSDDPEG DIPVLLQAVL ARSPNVFREK SMQNRYVQSG
MMMSQYKLSQ NSMHSSPASS NYQQTTISHS PSSRFVPPQT SSGNRFMPQQ NSPVPSPYAP
QSPAGYMPYS HPSSYTTHPQ MQQASVSSPI VAGGLRNIHD NKVSGPLSGN SANHHADNPR
HGSSDDYLHM VHRLSSDDGD SSTMRNAASF PLRSPQPVCS PAGSDGTPKG SRPPLILQSQ
PLPCSSPRDV PPDILLDSPE RKQKKQKKMK LGKDEKDQSE KAAMYDIISS PSKDSTKLTL
RLSRVRSSDM DQQEDMLSGM ENSNVSENDI PFNVQYPGQT SKTPITPQDV NRPLNAAQCL
SQQEQTAFLP ANQVPVLQQN TSIATKQPQT SVVQNQQQVS QQGPIYDEVE LDALAEIERI
ERESAIERER FSKEVQDKDK PLKKRKQDSY PQEAGGATGG NRPASQETGS TGNGSRPALM
VSIDLHQAGR VDSQASITQD SDSIKKPEEI KQCNDAPISV LQEDIIGNLK ATPENHPETP
KKKSDSELSK SEIKQNERLA ESKPNENRLV ETKSSESKLE TKIDTQTEEP KQNESRTTES
KQNESTTSEP KQNENRLSDI KPNDNKQNNG RSETTKARPE TPKQKGESRP ETPKQKSDGR
PETPKQKGDG RPETPKQKGE GRPETPKQKN EGRPETPKHR HENRRDSGKP STEKKPEVSK
HKQDIKSDSP RLKSERAEAL KQRPDGRSIS ESLRRDHDSK QKSDDRNESE RHRGDQSRVR
RPETLRSSNR NEHGIKSDGS KPDKLERKHR HESGDSRERP SSGEQKSRPD SPRVKQGDSN
KSRSDKPGFK SPNSKDDKRT EGNKTKVDSN KAHPDNKAEF PSYLLGGRSG ALKNFVIPKI
KRDKDGNITQ ETKKMEMKGE QKDKVEKMGL VEDLNKGAKP VVVLQKLSLD DVQKLIKDRE
DKSRSSLKPI KNKPSKSNKG SIDQSVLKEL PPELLAEIES TMPLCERVKM NKRKRSTVNE
KPKYAEISSD EDNDSDEAFE SSRKRHKKDD DKAWEYEERD RRSSGDHRRS GHSHEGRRSS
GGGRYRNRSP SDSDMEDYSP PPSLSEVARK MKKKEKQKKR KAYEPKLTPE EMMDSSTFKR
FTASIENILD NLEDMDFTAF GDDDEIPQEL LLGKHQLNEL GSESAKIKAM GIMDKLSTDK
TVKVLNILEK NIQDGSKLST LLNHNNDTEE EERLWRDLIM ERVTKSADAC LTTINIMTSP
NMPKAVYIED VIERVIQYTK FHLQNTLYPQ YDPVYRLDPH GGGLLSSKAK RAKCSTHKQR
VIVMLYNKVC DIVSSLSELL EIQLLTDTTI LQVSSMGITP FFVENVSELQ LCAIKLVTAV
FSRYEKHRQL ILEEIFTSLA RLPTSKRSLR NFRLNSSDMD GEPMYIQMVT ALVLQLIQCV
VHLPSSEKDS NSEEDSNKKV DQDVVITNSY ETAMRTAQNF LSIFLKKCGS KQGEEDYRPL
FENFVQDLLS TVNKPEWPAA ELLLSLLGRL LVHQFSNKST EMALRVASLD YLGTVAARLR
KDAVTSKMDQ GSIERILKQV SGGEDEIQQL QKALLDYLDE NTETDPSLVF SRKFYIAQWF
RDTTLETEKA MKTQKDEESS EGTHHAKEVE TTGQIMHRAE NRKKFLRSII KTTPSQFSTL
KMNSDTVDYD DACLIVRYLA SMRPFAQSFD IYLTQILRVL GENAIAVRTK AMKCLSEVVA
VDPSILARLD MQRGVHGRLM DNSTSVREAA VELLGRFVLC RPQLAEQYYD MLIERILDTG
ISVRKRVIKI LRDICIEQPT FPKITEMCVK MIRRVNDEEG IKKLVNETFQ KLWFTPTPHN
DKEAMTRKIL NITDVVAACR DTGYDWFEQL LQNLLKSEED SSYKPVKKAC TQLVDNLVEH
ILKYEESLAD SDNKGVNSGR LVACITTLFL FSKIRPQLMV KHAMTMQPYL TTKCSTQNDF
MVICNVAKIL ELVVPLMEHP SETFLATIEE DLMKLIIKYG MTVVQHCVSC LGAVVNKVTQ
NFKFVWACFN RYYGAISKLK SQHQEDPNNT SLLTNKPALL RSLFTVGALC RHFDFDLEDF
KGNSKVNIKD KVLELLMYFT KHSDEEVQTK AIIGLGFAFI QHPSLMFEQE VKNLYNNILS
DKNSSVNLKI QVLKNLQTYL QEEDTRMQQA DRDWKKVAKQ EDLKEMGDVS SGMSSSIMQL
YLKQVLEAFF HTQSSVRHFA LNVIALTLNQ GLIHPVQCVP YLIAMGTDPE PAMRNKADQQ
LVEIDKKYAG FIHMKAVAGM KMSYQVQQAI NTCLKDPVRG FRQDESSSAL CSHLYSMIRG
NRQHRRAFLI SLLNLFDDTA KTEVNMLLYI ADNLACFPYQ TQEEPLFIMH HIDITLSVSG
SNLLQSFKES MVKDKRKERK SSPSKENESS ESEEEVSRPR KSRKRVDSDS DSDSEDDINS
VMKCLPENSA PLIEFANVSQ GILLLLMLKQ HLKNLCGFSD SKIQKYSPSE SAKVYDKAIN
RKTGVHFHPK QTLDFLRSDM ANSKITEDVK RSIVKQYLDF KLLMEHLDPD EEEEEGEVSA
STNARNKAIT SLLGGGSPKN NAAAETEDDE SDGEDRGGGT SGSLRRSKRN SDSTELAAQM
NESVDVMDVI AICCPKYKDR PQIARVVQKT SSGFSVQWMA GSYSGSWTEA KRRDGRKLVP
WVDTIKESDI IYKKIALTSA NKLTNKVVQT LRSLYAAKDG TSS
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