ID A0A2U3XHF4_LEPWE Unreviewed; 926 AA.
AC A0A2U3XHF4;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=ERN2 {ECO:0000313|RefSeq:XP_006730876.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006730876.1};
RN [1] {ECO:0000313|RefSeq:XP_006730876.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006730876.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_006730876.1; XM_006730813.2.
DR AlphaFoldDB; A0A2U3XHF4; -.
DR STRING; 9713.A0A2U3XHF4; -.
DR GeneID; 102737555; -.
DR KEGG; lww:102737555; -.
DR CTD; 10595; -.
DR OrthoDB; 1630at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR CDD; cd09769; Luminal_IRE1; 1.
DR CDD; cd10422; RNase_Ire1; 1.
DR CDD; cd13982; STKc_IRE1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF15; SERINE_THREONINE-PROTEIN KINASE_ENDORIBONUCLEASE IRE2; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00564; PQQ; 4.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_006730876.1};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..926
FT /note="non-specific serine/threonine protein kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015483390"
FT DOMAIN 521..783
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 786..914
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 471..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 926 AA; 102155 MW; DB2E23E545522AD0 CRC64;
MASAARGCGP WLPLRLGFLL QLAALLRTPG PQVQALRPES LLLVSTLDGS LHALSKQTGD
LKWTLKDDPI IQGPMYVTET AFLSDPADGS LYILGTQKQQ GLMRLPFTIP ELVHASPCRS
SDGVFYTGRK QDAWFVVDPE SGKTQMTLTT EGPSTPRLYI GRTQYTVTMH DPKAPALCWN
TTYRRYSAPP MEGLPGKYMS HLASCGMGLL LTVDPGSGVV LWTQDLGMPV MGVYTWHQDS
LRQLPHLTLA RDTLHFLALR WGHIRLPASG PQDTATDFSA LDTQLLMTLY VGKDETGFYV
SKALIHTGVA LVPRGLTLAP MDGPTTEEVT LQVSGEREGS PSTAVRYPSG SVALPSQWLL
IGHHEPPPVL HTTMLRVHPT PQSGTAENRL SENTQAPALF LELLSLSHEK PWNLELHPEE
KTPDLYPGLG PQDLLVASLT AVLLGGWIIF LMRQQQRQLV EKQQQTLLAP ADPPHISQNA
QPLPSGATPQ GQKSLPSPSE QAQPVEDPEA EQLTVVGKIS FNPKDVLGRG AGGTFVFRGQ
LEGRAVAVKR LLRECFGLVR REVQLLQESD RHPNVLRYFC TEQAPQFHYI ALELCQASLQ
EYVENPELER WGLEPSMALQ QLMCGLAHLH SLHIVHRDLK PANVLIAGPD GPDGQGRVVL
SDFGLCKKLP AGRCSFSLCS GIPGTEGWMA PELLQLLPSD SPTRAVDIFS AGCVFYYVLS
GGSHPFGESL YRQANILAGT PSLTHLEEEA HDKVVARNLV EAMLSPLPQA RPSAHQVLAH
PFFWSRAKQL QFFQDVSDWL EKESEQGPLV TALEAGGSAV VRGDWHKHIS VPLQTDLRRF
RTYKGTSVRD LLRAMRNKKH HYRELPMEVR QVLGHVPDSF VQYFTARFPR LLVHTHGAMR
HCASESLFLP YYPPASRARE PCPAGS
//
