ID A0A2U3XHM7_LEPWE Unreviewed; 5172 AA.
AC A0A2U3XHM7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2021, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Hemicentin-1 {ECO:0000313|RefSeq:XP_006730990.2};
GN Name=HMCN1 {ECO:0000313|RefSeq:XP_006730990.2};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006730990.2};
RN [1] {ECO:0000313|RefSeq:XP_006730990.2}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006730990.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_006730990.2; XM_006730927.2.
DR STRING; 9713.A0A2U3XHM7; -.
DR KEGG; lww:102727379; -.
DR OrthoDB; 2917340at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 8.
DR CDD; cd00096; Ig; 6.
DR CDD; cd00255; nidG2; 1.
DR Gene3D; 2.40.155.10; Green fluorescent protein; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 39.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 6.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR006605; G2_nidogen/fibulin_G2F.
DR InterPro; IPR009017; GFP.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF8; WRAPPER_REGA-1_KLINGON HOMOLOG; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 6.
DR Pfam; PF07474; G2F; 1.
DR Pfam; PF07679; I-set; 28.
DR Pfam; PF13927; Ig_3; 10.
DR Pfam; PF00090; TSP_1; 6.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00682; G2F; 1.
DR SMART; SM00409; IG; 39.
DR SMART; SM00408; IGc2; 39.
DR SMART; SM00406; IGv; 14.
DR SMART; SM00209; TSP1; 6.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF54511; GFP-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 40.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS50835; IG_LIKE; 39.
DR PROSITE; PS50993; NIDOGEN_G2; 1.
DR PROSITE; PS50092; TSP1; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 348..434
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 437..524
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 582..672
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 679..765
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 770..856
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 861..955
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 960..1046
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1083..1171
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1175..1261
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1270..1358
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1363..1451
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1456..1544
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1549..1634
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1641..1727
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1732..1822
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1827..1916
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1921..2007
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2015..2103
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2108..2199
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2203..2300
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2303..2401
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2405..2496
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2500..2588
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2593..2683
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2688..2777
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2782..2872
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2877..2966
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2971..3053
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3064..3152
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3157..3245
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3250..3334
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3341..3429
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3434..3518
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3525..3613
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3616..3702
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3706..3792
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3797..3870
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3885..3972
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3977..4064
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4408..4630
FT /note="Nidogen G2 beta-barrel"
FT /evidence="ECO:0000259|PROSITE:PS50993"
FT DOMAIN 4644..4683
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4729..4766
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4809..4844
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4852..4892
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4969..5008
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 4648..4658
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4733..4743
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4973..4983
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 5172 AA; 562491 MW; 2B1EDA5C21C25EDF CRC64;
MGTWSTEIGP VTITTDPKKF QYELRELYVQ GGGDCPEMSI GAIKIALEIS LPGSFIYVFT
DARSKDYQLT HEVLQLIQQK QSQVVFVLTG DCDDRGHIGY KVYEEIASTS SGQVFHLDKK
QVNEVLKWVE EAVQSSKVHL LSTDHLEQAV NTWKIPFDPS LKEVTVSLSG PSPGIEIRNP
LGKLIKKGFG LNELLNIHNS AKVVNVREPE AGMWTVKTSS SGRHSVRITG LSTIDFRAGF
SRKPTLDFKK TVSRPVQGIP TYVLLNTSGI SVPARVDRLE LLSISGSSLK TIPVKYYPDR
KPYGLWNISD FIPPNEAFFL KVTGYDKDDY LFQRVSSVSF SNIIPDAPKV TMPKKTPGYY
LQPGRIPCSV ESLLPFTLSF VRNGLTLGVD QYLKESASVN WEIENVTLSD EGAYECIALS
STGTGRAQTF FDVSEPPPVI QVPDNVTVTP GERAVLTCLV ISAVDYNLTW QRNDRDARLA
DPARMRILAN LSLELRSVKF NDAGEYHCVV SSEGGSSAAS VFLTVQGDLE LRPSTFLLID
PLLGLLKIQE TQDLDAGDYM CVAVNDAGRA AGKITLDVGS PPVFIQEPAD VSVEIGSNVT
LPCYVQGYPE PKIKWQRSDI MPIFSRPFSV SSISQLRTGA LFISNLWAND KGTYICEAEN
QFGKIQSQAT ITVTGLVAPL IGISPSVTSV IEGQQLTLPC ALLAGNPIPE RRWLKNSAML
VQNPYITVRS DGSLHIERVR LQDGGQYTCV ASNVAGTINK TTTLDVHVLP TIQHGQQVLS
TIEGIPVTLP CKASGIPKPS IIWSKKGELI STSSAKFSAG ADGSLYVVSP GGEESGEYVC
TATNAAGYAK RKVQLTVYVR PRVFGDQRGL SQDKPVEISI LAGEEVTLPC EVKSLPPPII
TWAKETQLIS PFSPRHTFLP SGSMKIIETR VSDSGMYLCV ATNIAGNVTQ SVKLNVHVPP
KIQRGPKLMK VQVGQRVDIP CNAQGTPLPV ITWFKGGSAL LVDGVQHVSN LDGTLSIDQA
MLSDAGLYTC VATNIAGSDE TEITLQVQEP PTLEDLEPPY NTPFQERVAN ERIAFPCPAK
VPPTIKGGNV TTKVTALINS IIKLECETRG LPMPAITWYK DGQPVISSSQ ALYINKGQFL
HIPRAQVSDS GTYTCHATNV AGTAEKSFHV DVYVPPVIEG DLAVPLNKQV VIAHSLTLEC
KATGNPPPVL TWLKDGVPMK ASDNIRTEAG GKKLEIMSAL EVDRGQYVCV ATSVAGEKEI
KYEVDVLVPP AIEGGDETSY FIVMVNNLLE LDCQVTGSPT PTIMWLKDGQ LTDERDGFKI
LLNGRKLVIA QAQVSDTGLY RCVATNIAGD HEKEFEVTVH VPPTIKSSGL SERAIVKHKP
ITLQCIANGI PNPSITWLKD GQPVNTARGN LKIQSSGRVL QIAKALMEDA GRYTCVATNA
AGETQQHLQL HVHEPPSLED AGKMLNETVV VNNPIQLECK AAGNPFPVIT WYKDNRPLSG
STGVTFLKRG QIIDIESAQI TDAGIYKCVA INSAGATELF YSLQVHVPPS ISGSNNMVAV
VVNNLVRLEC EARGIPAPSL TWLKDGSPVS SFANGLQVLS GGRIVALTSA QISDTGRYTC
VAVNAAGEKQ RDIDLRVYVP PNIMGEEQNI SVLISQAVEL LCQSDAIPPP TLTWLKDGRP
LLKKPGLSIS ENGTVLKIEE TQVQDTGRYT CEATNVAGKT EKNYNVNIWV PPNIYGSDEL
AQLTVIEGNL ISLLCESSGI PPPNLIWKKK GSPVLADSAG RVRTLSGGRQ LQISVAEKSD
AGLYTCVASN VAGTAKKDYS LQVYIRPTIS NSGSHPTEII VTRGKSISLE CEVQGIPQPK
VTWMKDGRPL TKGRGMEILD EGRILQLKNI HVSDTGRYVC VAVNVAGMTD RKYDLSVHTP
PAITGNHGIP ENISVVEKNS VSLTCEASGI PLPSITWLKD GWPVNLSSSV RILSGGRTLR
LMQTRTEDGG QYICIVRNAA GEERKIFGLS VLVPPHIVGE NTLEDVKVKE KQSVILTCEV
TGNPVPEITW HKDGQLLQED DTHHIMSGGR FLKITNAQVS HTGRYACLAS NTAGDKSRSF
SLNVLVSPTI AGVDSDGGPE DVTVILNSPT SLVCEAYSYP PATITWFKDG TPLESNQNIR
ILPGGRTLQI LNAQEDNAGR YSCIATNEAG EMIKHYEVKV YIPPIINKGD LLGPGLSPKE
VKIKVNNTLT LECEAYAIPS ASLSWYKDGQ PLKSDDHVII AASGHTLQIK EAQISDTGRY
TCVASNIAGE DELDFDVNIQ VPPSFQKLWE MGNMLDSGRS GEAKDVIINN PISLYCETNA
APPPTLTWYK DGHPLTSSDR VLILPGGRVL QIPRAKVEDA GRYTCVAVNE AGEDALQYDL
RVLLPPVIKG ANSDLPEEVT VLVNKSTLME CLSSGSPAPR NSWQKDGQPL LEDGHHKFLS
NGRILQILNT QITDIGRYVC IAENTAGSAK KYFNLNVHVP PSVIGPNPEN LTVVVNNFIS
LTCEVSGFPP PDLSWLKNEQ PIKLNTNALI VPGGRTLQII RAKVSDGGEY TCIAINQAGE
SKKKVFLTVY VPPSIKDHGS ESLSVVNVRE GTSVSLECES NAVPPPVITW YKNGQMITES
THLEILADGQ MLHIKKAEVS DTGQYVCRAI NVAGRDDKNF HLNVYVLPSI EGPENEVVVE
TISNPVTLTC DATGIPPPTI AWLKNHKPIE NSDSLEVHIL SGGSKLQIAR SQHSDSGNYT
CIASNMEGKA QKNYILSIQV PPSIAGAEIP SEVSVLQGEN VELACNANGI PTPLIQWLKD
GKPINNSETE RIRVTADGST LNIYGALPSN VGKYTCVASN PAGEEDQIFN LNVYVPPAIR
GNKEEAEKLM TLVDTSINIE CRATGTPPPQ INWLKNGLPL PLSSHIRLLS GGQVIRIVRA
QVSDVAVYTC VASNRAGVDN KHYSLRVLVP PTLDNAMGTE EITIVKGSST SMTCFTDGTP
TPRMSWLRDG HPLGPNTRLT VSTQGMVLQL NKAETEDSGR YICIASNEAG EVSKHFILKV
LEPPHINGSE EPVEISVIVN NPLELTCFAS GIPTPKITWM KDGRPLPQTG QVQTLGGGEI
LQISSAQVED TGRYTCLASS TSGDDDKEYL VRVHVPPNIA GTDESQDFTV LRNRQVTLEC
KSDAVPPPVI TWLKNGERLQ ATPRIRILSG GRYLQINNAD LSDTANYTCV ASNIAGRTTR
GFILTVNVPP NIKSGPQSLI IHLNTSTVLE CLAEGVPTPR ITWRKDGAVL SASHARYSIL
ENGFLHIQSA HITDTGRYLC MATNAAGTDR RRIDLQVHVP PSIALGPTNI TVTVNVQTTL
ACEAAGIPKP SIRWRKNGHL LNVDQNQNSY RLLSSGSLVI ISPSVDDTAT YECTVTNDAG
EDKRTMDLTV QVPPSIADEP TDFLVTKRAP TVITCTASGV PFPSIHWTKN GIRLLPRGDG
YRILSSGAIE IFATELNHAG RYTCVARNAA GSAHRHVTLY VQESPVIQPQ PSELDVIVNN
PILLPCEATG TPSPFITWQK EGINVITAGK SHAVLPSGGL QISRAVREDA GTYMCVAQNP
AGTALGKIKL NVQVPPVISP HPEEYITALD KPISLPCEAG GFPPPDITWH KDGHAIVESI
RQRILSSGAL QIAFAQPDDA GQYTCMATNV AGSSSMSTKL IVHVPPRIRS TEIHYTVNEN
SQAILPCMAD GIPTPAINWK KDNVLLANLL GKYTIEPYGE LTLENVVPED SGTYTCVAKN
AAGEDTHMVS LTVHVLPTFT ELPGDTSLTK GEQLRLSCKA TGIPLPKLTW TFNNNIIPAH
FDSVNGHSEL VIKRVSKEDS GTYVCIAENS VGFVKAIGFV YVKEPPVFKG DYPSNWIEPL
GGNAVLNCEA KGDPAPTIQW NRKGVDIEIN HRIRQLVNGS LAIYGTVNED AGDYTCVATN
DAGVVERSMS LTLQSPPIIT LEPVETVINA GDKVILNCQA TGEPHPTITW SRQGHSVPWD
DRVNVLSNNS LHIAAAQKED TSEYECVARN LMGSVLVRVP VIVQVHGGYS QWSTWRACSV
TCGKGIQKRS RLCNNPSPAN GGKPCQGSDS EMRNCQRKLC PVDGSWSEWS PWEECTRSCG
RGNRTRTRTC NNPSAQYGGR PCEGNAIEII MCNIRPCPVH GAWGTWQPWS ACSESCGKGA
QIRTRLCNNP PPSFDGSYCD GAETQMQVCN ERHCPVDGKW AAWTSWSTCT VSCGGGARQR
TRECSDPVPL YGGSRCEGSD VQSDFCNNDP CPIHGNWSPW SGWGMCSRTC NGGQMRRFRT
CDNPHPSNGG RACGGPDSQI QRCNTDMCPV DGSWGNWHNW GQCSASCGGG EKTRKRLCNN
PVPSKSGRPC PGDATQVSRC NMQACPGGPQ RARGSVIGNI NDVEFGIAFL NATVTDSPTF
DTRIIHAKIT NIPRSLGPAM RKIVSILNPI YWTTAKEIGE AVNGFTLTNA VFKRETQVEF
ATGEILRMTH TARGLDSDGA LLLDIVVSGY VLQLQSPAEV TVKDYTEDYI QTGPGQLYAY
STRLFTIDGV SVPYMWNHTV FYDEAQGRMP FLVETLHASS VESDYNQLEE TLAFKIHASI
SKGDRSNQCP SGFALDSVGP FCADEDECAA GSPCSQICHN TVGTYYCSCS KGLTIAADGR
TCQDIDECAL GGHTCHAGQD CDNTIGSYRC VVRCGMGFRR TSDGLSCQDI NECQESSPCH
HRCFNAIGSF HCGCEPGYQL KGRKCVDVNE CRQNVCRPDQ HCKNTRGGYK CIDLCPNGMT
KAKNGTCIDI DECKDGTHQC RYNQICENTR GSYRCVCPRG FRSQGVGRPC MDINECEQVP
KPCAYQCSNT PGSFKCICPP GQHLLGDGKS CAGLERLPHY GTQYSSYNLA RFSPMRNNYQ
LQQHYRQYSH LYSSYSEYRN SRTSLSRTRR TIRKTCPEGS EESRDTCVDI DECENRDICQ
HECKNTFGSY HCICPPGYQL MLNGKVCQDV DECLEQSVRC GPNRMCFNMR GSYQCIDTPC
PANYQRDPVS GFCLKNCPPN DLECALSPYA LEYKLVSLPS GIAANQDLIR LVAYTQDGVM
HPRTTFLMVD EEETVPFALR DENLKGVVYT RRPLREPETY RMRVRASSYS ANGTIEYQTT
FIVYIAVSAY PY
//
