ID   A0A2U3XKU5_LEPWE        Unreviewed;       264 AA.
AC   A0A2U3XKU5;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Thymidine kinase 2, mitochondrial isoform X1 {ECO:0000313|RefSeq:XP_006732110.1};
GN   Name=TK2 {ECO:0000313|RefSeq:XP_006732110.1};
OS   Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC   Leptonychotes.
OX   NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006732110.1};
RN   [1] {ECO:0000313|RefSeq:XP_006732110.1}
RP   IDENTIFICATION.
RC   TISSUE=Liver {ECO:0000313|RefSeq:XP_006732110.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DCK/DGK family.
CC       {ECO:0000256|ARBA:ARBA00007420}.
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DR   RefSeq; XP_006732110.1; XM_006732047.2.
DR   AlphaFoldDB; A0A2U3XKU5; -.
DR   STRING; 9713.A0A2U3XKU5; -.
DR   GeneID; 102737065; -.
DR   KEGG; lww:102737065; -.
DR   CTD; 7084; -.
DR   OrthoDB; 5393913at2759; -.
DR   Proteomes; UP000245341; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019136; F:deoxynucleoside kinase activity; IEA:InterPro.
DR   GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:UniProt.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd01673; dNK; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR002624; DCK/DGK.
DR   InterPro; IPR031314; DNK_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR   PANTHER; PTHR10513:SF35; THYMIDINE KINASE 2, MITOCHONDRIAL; 1.
DR   Pfam; PF01712; dNK; 1.
DR   PIRSF; PIRSF000705; DNK; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_006732110.1};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          52..258
FT                   /note="Deoxynucleoside kinase"
FT                   /evidence="ECO:0000259|Pfam:PF01712"
FT   REGION          13..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..48
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        132
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-1"
FT   BINDING         56..64
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
FT   BINDING         191..195
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
SQ   SEQUENCE   264 AA;  30735 MW;  E2E172082F160876 CRC64;
     MLLRPLRSWA ARALRREGPG SPGPGRGTRG VQRPAWPRDK DRENEKEKKS VICVEGNIAS
     GKTTCLEFFS NTTGIEVLQE PVSKWRNVRG HNPLGLMYRD ACRWGLTLQT YVQLTMLDHH
     TRPQTSPVRL MERSIHSARY IFVENLYRSG KMPKVDYVIL SEWFDWIVRN IDVSVDLIVY
     LRTTPETCYQ RLRLRCREEE TVIPLDYLNA IHHLYEEWLI QGGLFPVTAP VLVIEADHDV
     QKMLKLFEQN RDRILTPETQ KHGS
//