ID A0A2U3XL42_LEPWE Unreviewed; 278 AA.
AC A0A2U3XL42;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Oxidized low-density lipoprotein receptor 1 {ECO:0000256|ARBA:ARBA00041191};
DE AltName: Full=Lectin-like oxidized LDL receptor 1 {ECO:0000256|ARBA:ARBA00041686};
DE AltName: Full=Lectin-type oxidized LDL receptor 1 {ECO:0000256|ARBA:ARBA00041771};
GN Name=OLR1 {ECO:0000313|RefSeq:XP_006732182.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006732182.1};
RN [1] {ECO:0000313|RefSeq:XP_006732182.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006732182.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer; disulfide-linked. May form a hexamer composed of 3
CC homodimers. Interacts with HSP70. {ECO:0000256|ARBA:ARBA00038751}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004193};
CC Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}. Membrane raft
CC {ECO:0000256|ARBA:ARBA00004285}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
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DR RefSeq; XP_006732182.1; XM_006732119.2.
DR AlphaFoldDB; A0A2U3XL42; -.
DR STRING; 9713.A0A2U3XL42; -.
DR GeneID; 102740969; -.
DR KEGG; lww:102740969; -.
DR CTD; 4973; -.
DR OrthoDB; 2883044at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR CDD; cd03593; CLECT_NK_receptors_like; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR013600; Ly49_N.
DR InterPro; IPR033992; NKR-like_CTLD.
DR PANTHER; PTHR47298; OXIDIZED LOW-DENSITY LIPOPROTEIN RECEPTOR 1; 1.
DR PANTHER; PTHR47298:SF1; OXIDIZED LOW-DENSITY LIPOPROTEIN RECEPTOR 1; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF08391; Ly49; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288,
KW ECO:0000313|RefSeq:XP_006732182.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_006732182.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 155..269
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 92..123
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 9..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 278 AA; 31936 MW; B74EC43FBDC099AE CRC64;
MNLEMTFDDF KSKTMKDQPD QKPNRKKAEG PHFLSSRWWY PTAVTLGILC LGLLVTLIML
TVQLLQVSDL LKQQQANLTN QEIILEGQIL AQKQAEKSSQ ESERELKETI ETLNQKLDEN
SKKQMELHHQ NLNLQEALRK AANFSGPCPQ DWLWHEENCY LFSSGPFNWE KSQENCLSLD
AQMLKINSTD DLKFIRQTSA HSNFPFWMGL SLRKPSSAWL WEDGSPLMPH LFRLQGPVSQ
NYPSGNCAYI QRGTVFADNC ILTAFSICQK KANLLRAQ
//
