ID A0A2U3XL83_LEPWE Unreviewed; 420 AA.
AC A0A2U3XL83;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Dynein axonemal assembly factor 4 {ECO:0000256|ARBA:ARBA00024430};
GN Name=DNAAF4 {ECO:0000313|RefSeq:XP_006732098.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006732098.1};
RN [1] {ECO:0000313|RefSeq:XP_006732098.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006732098.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, neuron projection
CC {ECO:0000256|ARBA:ARBA00004487}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Dynein axonemal particle
CC {ECO:0000256|ARBA:ARBA00024190}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_006732098.1; XM_006732035.2.
DR AlphaFoldDB; A0A2U3XL83; -.
DR STRING; 9713.A0A2U3XL83; -.
DR GeneID; 102731951; -.
DR KEGG; lww:102731951; -.
DR CTD; 161582; -.
DR OrthoDB; 167568at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0120293; C:dynein axonemal particle; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003341; P:cilium movement; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd06469; p23_DYX1C1_like; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR037894; CS_DYX1C1.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46492; DYNEIN ASSEMBLY FACTOR 4, AXONEMAL; 1.
DR PANTHER; PTHR46492:SF1; DYNEIN AXONEMAL ASSEMBLY FACTOR 4; 1.
DR Pfam; PF04969; CS; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51203; CS; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT DOMAIN 3..87
FT /note="CS"
FT /evidence="ECO:0000259|PROSITE:PS51203"
FT REPEAT 366..399
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT COILED 104..156
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 420 AA; 48484 MW; 2EE588D24067A09A CRC64;
MPLQVSDYNW QQTKTAVFIS VPLRGVCVRD VDVFCTENYL KVNFSPFLFE VFLYAPIDDE
NSKAKIGNDT IVFTLYKKEV AMWETLSVSG VDKEMMQRIR EKSILQAQER AKEAAEAKAA
ARREDQKYAL NVMMKIEEEE RKKIEDMKEN ERLKATKELE AWKECQRKAE EQKGIQREEK
FCEQGKQIEE ERNKLKHKSL TRIAASRNLA TKGRNSENIF LEKLKEDSIP APRSVGSIKI
NFTPRVFPTA LRESQVAEEE EWLHKQAEAR RALNTDIPEL SDLKEEEKNP EWLKDKGNKL
FAKENYLAAI NAYNLAIRLN NKIPLLYLNR AACHLKLKNL HKAIEDSSKA LELLTPPVAD
NANGRMKAYI RRGTAFCQLE LYIEGLQDYE AALKIDPSNK IVQNDAEKIR KIIQGTELKS
//
