ID A0A2U3XLP4_LEPWE Unreviewed; 1997 AA.
AC A0A2U3XLP4;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRB {ECO:0000313|RefSeq:XP_006732405.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006732405.1};
RN [1] {ECO:0000313|RefSeq:XP_006732405.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006732405.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 3 subfamily. {ECO:0000256|ARBA:ARBA00025789}.
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DR RefSeq; XP_006732405.1; XM_006732342.2.
DR STRING; 9713.A0A2U3XLP4; -.
DR GeneID; 102749736; -.
DR KEGG; lww:102749736; -.
DR CTD; 5787; -.
DR OrthoDB; 5402037at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 13.
DR CDD; cd14617; R-PTPc-B; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 16.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF2; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE BETA; 1.
DR Pfam; PF00041; fn3; 16.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 17.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 16.
DR PROSITE; PS50853; FN3; 12.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_006732405.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1997
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015725024"
FT TRANSMEM 1616..1642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 113..205
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 291..378
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 379..468
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 469..558
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 642..733
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 734..820
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 821..908
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 909..996
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1087..1174
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1175..1262
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1263..1356
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1357..1448
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1703..1963
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1878..1954
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1997 AA; 224037 MW; D564201695B3B47D CRC64;
MLSHGAGLAL CTALSLLQTG LGEPVRCNFT LTESKVSSRS ASLQWRTLGS PCNFSLIYSS
DTSGVAWCHP TRIDNTTYGC YPKDLQAGTT YNFRIVSLDG EERTVVLQTD PLPPAKFEVS
KEKTTSTSLH VWWTPSSGKV TWYEIQLFDN NQKIQETQIQ ESTSWNEHTF FNLTAGNKYN
IAITAVSGEK RSLTIYTNGS TVPSAVKDIN ISAKTNSLLL SWSHGSGNVE RYQLLLMDKD
VLVHGSVVDK HATSFSFHGL TPGHLYNLTI VTEAAGLQNY RWKPARTTPM EVSNLKVTND
GTLTSLKVKW QRPSGNVDSY NITLFHQGTI KESRTLAPQV TETQFKDLIP GRLYQVTISC
VSGELSAQKM AVGRTVPEKV GNLEVNSNGS IRSLIVSWSP PAGDWEQYRI LLFNDSVVLL
NITVGKEETH YAIDDVGLIP GRQYEVEVTV ESGNLKNSKR CQGRTVPLAV LQLRVKHANE
TSLGVMWQTP VAEWEKYIIS LADRDLLLIH KSLPKDAKEF TFTDLVPGRK YIATVTSISG
DLKNSSSTKG RTVPAQVTGL YVANQGTTSS LFTNWTQALG DIEFYQVLLI HENVVIKNES
VSSETSRYSF HSLKSGSLYS VVVTTVSGGI SSRQVVVEGR TVPSSVSGVT VNNSGRNDYL
SISWLPAPGD VDNYVVTLSH GSRVVQSLVI AKSVSECSFS SLTPGRLYNV TITTRSGKYE
NHSFSQERTV PDKVQGVSIS NSARSDYLKV SWVHATGDFD HYEVTIKNKN NFIQTKSIPK
PENECVFVKL VPGRLYSVTV STRSGQYEAS EQGNGRTIPE PVRDLTLRNR STEDLLVTWS
RADGDVDQYE IQLLFNDMKV FPPFHLVNTA TEYRFTSLTP GRQYKILVLT ISGEVQQSAF
IEGFTVPSAV KNIHVSPNGA TDSLTVNWTP GGGDVDSYTV SAFRQNQKVE SQTISKHVSE
HTFHRLEAGE QYQIVIASVS GSLKNQIDAV GRTVPASVQG IIADNAYSSH SLMVSWQKAV
GVAERYEILL LNDKGILLSN TSEPAATKQH KFEDLTPGKK YKIQILTVSG GLFSKEAQTE
GRTVPAAVTN LRITENSTRH LSFSWTTSEG ELNGYNIFLY NPDRTLQERA QVDPQVQSFS
FQNLLQGRMY KMVIVTHSGE LSNESFIFSR TVPASVSNLR GSNRNMTDSL WFSWSPASGD
FDFYELILYN PNGTKKENWR DKDLTEWRFH GLIPGRKYTL CVVTHSGDLS NKLTGESRTA
PTPPSLMSFA DVTNTSLAIT WKGPPDWTDY DDFELQWSPR DAITVFNPYS NRKSEGRIIY
GLRPGRSYQF SVKTVSGDSW KTYSRPIFGS VRTKPDKIQN LHCRPQNSTA IACSWIPPDS
DFDGYNIECR KMDTQEVEFS RKLEKEKSLL NIMMLVPHKR YLVSIKVQSA GMTSEVVEDS
TITMIDRPPP PPPHIRVNKK DVLISKSSIN FTFNCSWFSD TNGAVKYFTV VVREAEGSDE
LKPEQQHPLP SYLEYRHNAS IRMYQTDYFA SKCAESPDSN SKSFNIKLGA EMESLGGKCD
PNQQKFCDGP LKPRTAYRIS IRAFTQLFDE DLKEFTKPLY SDTFFSLPIT TESEPLFGVI
EGVSAGLFLI GMLVAVVALF ICRQKASHGR ERPSARLSIR RDRPLSVHLN LGQKGNRKTS
CPIKVNQFEG HFMKLQADSN YLLSKEYEDL KDVGRNQSCD IALLPENRGK NRYNNILPYD
ASRVKLSNVD DDPCSDYINA SYIPGNNFRR EYIATQGPLP GTKDDFWKMA WEQNVHNIVM
VTQCVEKGRV KCDHYWPADQ DSLYYGDLIL QMLSESVLPE WTIREFRICS EEQLDTHRLI
RHFHYTVWPD HGVPETTQSL IQFVRTVRDY ISRSPGAGPT VVHCSAGVGR TGTFIALDRI
LQQLDSKDSV DIYGAVNDLR LHRVHMVQTE CQYVYLHQCV RDVLRARKLR SEQENPLFPI
YENVNPEYHR DPGYSRH
//
