ID A0A2U3XRG8_LEPWE Unreviewed; 3065 AA.
AC A0A2U3XRG8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Cubilin {ECO:0000313|RefSeq:XP_006734061.1};
GN Name=CUBN {ECO:0000313|RefSeq:XP_006734061.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006734061.1};
RN [1] {ECO:0000313|RefSeq:XP_006734061.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006734061.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_006734061.1; XM_006733998.2.
DR STRING; 9713.A0A2U3XRG8; -.
DR GeneID; 102750726; -.
DR KEGG; lww:102750726; -.
DR CTD; 8029; -.
DR OrthoDB; 2917265at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 22.
DR CDD; cd22201; cubilin_NTD; 1.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 22.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR47761:SF1; C-TYPE LECTIN; 1.
DR PANTHER; PTHR47761; C-TYPE LECTIN-RELATED; 1.
DR Pfam; PF00431; CUB; 22.
DR Pfam; PF00008; EGF; 3.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR SMART; SM00042; CUB; 22.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 7.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 23.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01180; CUB; 22.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..3065
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015477332"
FT DOMAIN 129..165
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 167..208
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 260..301
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 346..382
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 392..427
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 429..465
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 471..556
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 557..668
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 672..782
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 788..902
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 906..1018
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1019..1130
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1132..1247
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1251..1360
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1361..1475
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1479..1591
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1593..1704
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1719..1832
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1833..1954
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1958..2075
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2077..2188
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2192..2305
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2310..2427
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2429..2541
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2545..2716
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2720..2837
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2837..2949
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2953..3065
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 155..164
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 198..207
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 396..406
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 417..426
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 455..464
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1361..1388
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 3065 AA; 335503 MW; 6FBB0C868ECAD53F CRC64;
MSSSFLWSLV ILLTFAESNG GTGELELQRQ KRSTELQQPR MAAERGNLVF LAGTAQNIEF
RTGSLGKIKL NEEDLGECLH QIQRNKDDII DLKRSAVGLP QNISSQIHQL NSKLVDMERK
FQNLQQTVDR KVCSSNPCQN GGTCLNLHDS FYCICPSQWK GPLCSVDVNE CAIYSGTPLG
CQNGATCENT AGSYSCLCSP ETHGPQCASR YDDCEGGSKE LCVHGICEDL VRVQADQPRY
SCICDVGWTS PLNGPACVLD IDECSLQHSP CSTLAQCFNT PGSFYCGACP TGWQGNGYSC
QDINECEINN GGCSVAPPVT CVNTFGSYHC QACPPGYQGN GRVCTLIDIC SVSNGGCHPD
ASCSSVLGSL PLCTCLPGYT GNGYGPNGCV QLSNICQSRP CLNGQCIETV SGYLCKCESG
WAGINCTENI NECLSNPCLN GGTCVDGINA FSCECTRFWT GLLCQIPQQV CGGSLSGMSG
SFSYMSPDVG YVHDVNCFWV IRTEEGKVRD DQTLLGKVCG NETISNIKSI TNSIWIRLKI
DASVVRASFR AVYQVACGGE LTGEGVIRSP FYPNVYPGER ICRWTIHQPQ SQVVILNFTA
FEIESSTHCD TDYIEIGSSS ILGSPENKKY CGTDIPSFIT SVYNFLYVIF VKSSSTENRG
FMAKFSSADL ACGKILTEST GIIQSPGHPN IYPHGINCTW HILVQPGHLI HLIFRVFHLE
FHYNCTNDYL EVYDTGSETS LGRYCGKSIP PSLTSSTNSL MLIFVADSDI AYEGFLINYE
AIDASAACME DYTEESGTFT SPNFPDNYPN NLKCIYRITV ETSQQIALHF TNFSLEEAIG
GHCIGDFVEI RDGGYESSPP LGTYCGSNPP PRIISHSNKL WLQFKSDFLG SGPGFSVYWD
GSLTGCGGNL TTPTGVFTSP NYPMPYYHSS ECYWRLKSSH GSPFELEFED FHLENHPNCM
SDYLAVYDGP STSSHLLSQL CGNEKPPLIR SSGDSMFLKF RTDEGQQGGG FLAKYQQTCR
NVVIVNRTYG ILESIHYPGP YSDNQRCNWT IQASIGNTVN YTFLAFELEN HINCSTDYLE
LHDGPRRIGR YCGTDMPPTG STTGSKLQVL FYTDGVSHHE KGFQMQWFIH GCGGELSGTM
GSFSSPGYPN TYPPNKECLW YITTAPGSSI QLTIHDFDVE YHVRCNFDVL EIYGGPDFHS
PRISQLCAQR SSENPMQVSS TGNELAIRFK TDSSVNGRGF NASWQAVPGG CGGIFQAPNG
EIHSPNYPSP YRRNTDCSWV IRVERNHRVL LNFTDFDLEP QDSCITAYDG LSATTTRLAR
VCGRQLLANP ITSSGNSLFL RFQSGPSRQS RGFRAHFRQA CGSYILTDSF DTISSPLFPA
KYPNNQNCSW IIQAQPPFNH ITLSFDHFGL ESSTTCTQDF IEILDGDYDD APLRGRYCGT
SMPHPITSFS HALTLRFVSD SRANSEGFHA TYAASSSACG GTFHMAEGIF NSPGYPEVYP
SNVECVWNIV SSPGNRLQLS FITFQLEDSR DCSRDFVEVR EGNATGPLVG RYCGNVLPLN
YSSIVGHILW IRFVSDGSGS GTGFQATFTK IFGNDNIVGT HGKVASPLWP GRYPHNSNYQ
WIVNVNASQV IHGRILEIDI EAAPGCYYDK LRIYDGHGVH SRLIGTYCGT QTTTFSSSRN
SLTFQFSSDS SVTGKGFLLE WFAVNVSVGP LPTIATGACG GFLRTGDAPV FLFSPGWPES
YSNNVDCMWL IQAPDSTVEL NILSLDIEAH RTCDYDKLVI RDGDSNLAPQ LAVLCGREIP
GPIRSTGEYM FIRLTSDFSV TGAGFNASFH KSCGGYLHAD RGIITSPQYP ETYSPNLNCS
WHVLVQSGLT IAVHFEQPFQ IPNGDSSCSQ GDYLVLKNGP DIYSPPLGLH GGNGHFCGSH
PSSTLFTSDN QMFVQFISDA SNGGQGFKIK YEAKSLACGG NIYIHDVDSA GYVTSPGHPD
NYPQHADCTW LLAAPPGKLI RLQFEDQFNI GETPNCTSNY LELRDGADSN APVLSKVCGR
SLPRSQLSSG DVMYLRFRSD NSPTQVGFKI KYAIAHCGGR VTGQSGVIES GYPTLPYRDN
LFCEWHLEGP SGHYLTIHFE DFNLQNSSGC EKDFVEIWEN HTSGSLLGRY CGNTIPDSID
TSSNVALVRF VTDGSLTASG FRLQFESSME ECGGDLQGPT GTFTSPNYPN PNPHGRVCEW
RITVQEGRRI TLTFNNLSLE ARPSCSSERV TIFNGIRSNS PQLEKLCSNV NVSDAIRSSG
NTMKVVFFTD GSRPYGGFSA SYTSSEDAVC GGSLTHFPEG NFTSPGYNGV SNYSRNLNCE
WTLSNPNQGN SSMYIQFEDF YLESHQDCQF DVLEFRASNA DGPLMWRLCG PSKPTVPLVT
PYPQVWIHFV TNEHVEHVGF HAEYSFTDCG GIQLGESGVI TSPNYPASYD SLTHCSWLLE
APEGHTITLT FSDFDIEAHA TCVWDSVTVR NGGSPGSPII GQYCGSSNPG TIQSGSNQLV
VIFNSDHSVQ NGGFYATWNT QTLGCGGNFT NPSGYILSPN YPKQYDNNMN CTYIIEADPL
SLVFLTFVSF HLEGPRQGCG GYLTGSNNTF ASPDSDSNGR YDKNLNCIWF ITAPVNKLIK
LTFSTFALEA QSILQRCIYD YVKLYDGDSE NANLAGTFCG STVPAPFISS GNFLTVQFVS
DATLEREGFN ATYTLVDMPC GGTYNATWTP QSISSPNSSN PEILFSMCTW VLEAPPHQQV
KITVWALQLL SQDCDQNYLE FQDSPESHAN PGLLVCGRNA SATPTFYSSG STAIVIFKSE
VLSGNSRVGF TYQIAGCNRD YNKAFGNLKS PGWPDNYDNN LDCTVILTAP QNHTISLFFH
SFGIEDSSEC THDFLEVRNG SDSSSPLLGT YCGTLLPNPI FSQNNELYLR FKSDRATSSH
GYEILWTSSP SGCGGTLFGD SGSFTSPSYP GTYPNNTHCE WAITAPAGRP VTISFYFISI
DDPGDCVQNY LILYSGPDAN SPSSGPYCGA DTNIAPFMAS SPRVFIKFHA EYAVHPSAFR
LTWDS
//
