ID A0A2U3XRQ0_LEPWE Unreviewed; 1889 AA.
AC A0A2U3XRQ0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Abnormal spindle-like microcephaly-associated protein isoform X2 {ECO:0000313|RefSeq:XP_006734124.1};
GN Name=ASPM {ECO:0000313|RefSeq:XP_006734124.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006734124.1};
RN [1] {ECO:0000313|RefSeq:XP_006734124.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006734124.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_006734124.1; XM_006734061.1.
DR GeneID; 102745763; -.
DR CTD; 259266; -.
DR OrthoDB; 53079at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR CDD; cd21223; CH_ASPM_rpt1; 1.
DR CDD; cd21224; CH_ASPM_rpt2; 1.
DR Gene3D; 1.20.5.190; -; 6.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22706:SF1; ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ISOFORM X1; 1.
DR PANTHER; PTHR22706; UNCHARACTERIZED; 1.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 7.
DR SMART; SM00033; CH; 2.
DR SMART; SM00015; IQ; 12.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 6.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341}.
FT DOMAIN 917..1053
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1107..1258
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1889 AA; 217308 MW; 8FE7E75F7EBB0753 CRC64;
MATRRVGRSW EVSPTERRPP AGLRGTVAED AAASPPVLSL SHFCRSPFLC FGDVRLGASR
TLPLVLDNPN DEVAEVKISH FPAAEQGFSV SQRWFELQPK EKIVISVNWT PLKEGRVREI
VTFLVNDVLK HQAILLGNAE EQKKKKRSLW NTSNKKKMSA SSSNKRISCI QNVNKTFCVS
QNVDRVRNPL QACENLAMNE GCSPTENSSL ILEENKIPIS PISPIFKECH SETSLPLSVR
RSTTYTSLHA CENGELLKVE GAGVLEDFNF SEKVANETSF NSTNNINGQI EENSKLILTP
NCSSTLNITQ SQGNFLSPDS FVNNSRAANN ELEVVACLSS DTFMNNNSKH VHLESKTVHD
NYRTILSPDS FINDNYGLNQ DLESESINPI LSPNQFVKDN MAYICISQQT CKLSPSSNKN
SQFSQSPQDQ RTNGVLPHIP ECQGSESPKA IFEEPKALEM KSNCYSSTKN QPKFSAIQDS
YSHDKLKRRP ILSATVTKSK PTCTRENQKE TNKPKAKRCL NSVAGKFETV TDNQKEKDGF
QSCLPVIDPV CNKSVSYKNV ITPPSKTTLV ARKRKSEGDR DEANVRITVT EHTEVQEIKR
IHFSPVESKT STVKKMKKLV IPISKHMNRE KLNLKKKTDS LVYRTPNSKT NKRTKPIVAV
AQSTLTFIKP LKTDIPRHPM PFAAKNMFYD ERWKEKQEQG FTWWLNFILT PDDFTVKTNI
SEVSAATLLG VESQHKISVL RAPTKDEMSL RAYTARCRLN RLRRAACRLF TSEKMVKAIK
KLEIEIEARR LIVRKDRHLW KDVGERQKVL NWLLSYNPLW LRIGLETIFG ELLSLEDNSD
VMGLAVFILN RLLWNPDIAA EYRHPTVPHL YRDGHEEALS KFTLKKLLLL VCFLDYAKIS
KLIDHDPCLF RKDAEFKTSK DILLAFSRDF LSGEGDLSRH LSLLGLPVNH VQTPFDEFDF
AITNLAVDLQ CGVRLVRIME LLTRDWNLSK KLRIPAISRL QKMHNVDIVL QILRSQGIQL
NDENGNTILS KDIVDRHREK TLALLWKIAF AFQVDISLNL DQLKEEIDFL KHTQSMKKTM
SARSCHSDAI ISKKKDKRNS GSFEQYSESI KLLMEWVNAV CAFYNKKVEN FTVSFSDGRV
LCYLIHHYHP YYVPFDAICQ RTTQTVECTQ TGSVVLNSSS ESDGSSLDLS LRAFDHENTS
ELYKELLENE KKNFQLVRSA VRDLGGIPAM INHSDMSNTI PDEKVVITYL SFLCARLLDL
CKEARAARLI QTTWRKYKLK TDLKRQQERD KAARIIQSAI IAFLTKQRLK KQINATLTIQ
KYWRRLLAQR KLLMLKKEKL EKVQNESALV IQAMWKSYKT RKYLHKVKAA CKIQAWYRYW
KARKEYLAVL KAVKIIQGCF YTKQERTRFL NVRASTIIIQ RKWRATLAGR IAREYFLMMK
RHRAACLIQA NFRRYKGRQV FLRQKSAALT IQRYIRARKD GKCERIKYVE LKKSTVVLQA
LVRGWLVRKR ILEQKTRIRL LHFTAAAYYH LSAFRIQRAY KLHMALKNAN KQVNSVICIQ
RWFRTTLQQK RFAQKYNSII RSQHEIQECL SQQNRAASVI QKAVRRFLLC KKQEKFNNGI
SKIQALWRGY SWRKKNDCTK IKAIRLSLQL VNREIREENK LYKRTALALH YLLTYKHLSA
ILEALKHLEV VTRLSPLCCE NMAQSGAVSK IFVLIRSCNR SVPCMEVIRY AVQVLLNVAK
YEKTTAAVYD VENCIDTLLD LLQMYREKPG DKVADKGGSI FTKTCCLLAV LLKTTNRASG
VRSRSKVVDR IYSLYKLTAR KHKMNTERIL YKQKMNSSIS IPFIPETPVR TRIVSRLKPD
WVLRRDKMEE ITNPLQAIQM VMDTLGIPY
//
