ID A0A2U3XX39_LEPWE Unreviewed; 402 AA.
AC A0A2U3XX39;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Tumor necrosis factor receptor superfamily member 3 isoform X3 {ECO:0000313|RefSeq:XP_006736030.1};
GN Name=LTBR {ECO:0000313|RefSeq:XP_006736030.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006736030.1};
RN [1] {ECO:0000313|RefSeq:XP_006736030.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006736030.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR RefSeq; XP_006736030.1; XM_006735967.2.
DR AlphaFoldDB; A0A2U3XX39; -.
DR GeneID; 102727100; -.
DR CTD; 4055; -.
DR OrthoDB; 5320298at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048534; P:hematopoietic or lymphoid organ development; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR CDD; cd10578; TNFRSF3; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR017349; TNFR_3_LTBR.
DR InterPro; IPR033997; TNFRSF3_N.
DR PANTHER; PTHR47607; TUMOR NECROSIS FACTOR RECEPTOR SUBFAMILY MEMBER 3; 1.
DR PANTHER; PTHR47607:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 3; 1.
DR Pfam; PF00020; TNFR_c6; 3.
DR PRINTS; PR01920; TNFACTORR3.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_006736030.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 204..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..61
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 23..61
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 63..105
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 63..105
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REPEAT 150..191
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 150..191
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..375
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 24..39
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 40..53
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 43..61
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 64..79
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 151..166
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 402 AA; 43842 MW; FFF7F2CB305009C9 CRC64;
MEATEASLAS QLKKPPYHTE NQTCRDREKE YYEPKHQVCC SRCSPGMHVS AECSRSQDTV
CALCPENSYN EHWNHLSICQ LCRPCDQMLG FEETVPCTSR RKTQCRCQPG MFCVHWDTEC
VHCEPLSDCP PGTEAQLTDE VGAANRNCVP CKAGHFQNTS SPTARCQPHT RCEEQGLVEA
VPGTAQSDTS CRNPPEHPEM PGTVMVLAIL LPLASFLFLT TVLACTWKSH PSLCRKLGSL
LKRRPEGEES NSADGSWELP RVNPHFPDLV KPLLPFPRDT ALASARLPAP PSLEEEVLQQ
QSPLSQAREL EPELPEQSQV AHGTNGIHVT GGSVTVTGNI YIYNGPVLGG ARGPGDPPAS
PEPPYPTPEE GAPGPPGLST PYQEDGKAWH LAETETLGCH AL
//
