ID A0A2U3XXP3_LEPWE Unreviewed; 547 AA.
AC A0A2U3XXP3;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Lamin-B1 {ECO:0000313|RefSeq:XP_006736232.1};
GN Name=LMNB1 {ECO:0000313|RefSeq:XP_006736232.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006736232.1};
RN [1] {ECO:0000313|RefSeq:XP_006736232.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006736232.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Lamins are components of the nuclear lamina, a fibrous layer
CC on the nucleoplasmic side of the inner nuclear membrane, which is
CC thought to provide a framework for the nuclear envelope and may also
CC interact with chromatin. {ECO:0000256|ARBA:ARBA00037635}.
CC -!- SUBCELLULAR LOCATION: Nucleus lamina {ECO:0000256|ARBA:ARBA00024186}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR RefSeq; XP_006736232.1; XM_006736169.2.
DR AlphaFoldDB; A0A2U3XXP3; -.
DR STRING; 9713.A0A2U3XXP3; -.
DR GeneID; 102745662; -.
DR KEGG; lww:102745662; -.
DR CTD; 4001; -.
DR OrthoDB; 72418at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR GO; GO:0005652; C:nuclear lamina; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.40.1260; Lamin Tail domain; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 2.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR001322; Lamin_tail_dom.
DR InterPro; IPR036415; Lamin_tail_dom_sf.
DR PANTHER; PTHR45721; LAMIN DM0-RELATED; 1.
DR PANTHER; PTHR45721:SF3; LAMIN-B1; 1.
DR Pfam; PF00038; Filament; 2.
DR Pfam; PF00932; LTD; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR SUPFAM; SSF74853; Lamin A/C globular tail domain; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
DR PROSITE; PS51841; LTD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023289};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Prenylation {ECO:0000256|ARBA:ARBA00023289};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341}.
FT DOMAIN 32..349
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT DOMAIN 391..507
FT /note="LTD"
FT /evidence="ECO:0000259|PROSITE:PS51841"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 29..211
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 247..331
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 353..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 61472 MW; F31EEFDB4B643B4A CRC64;
MATATPVPPR SGSRASAPAT PLSPTRLSRL QEKEELRELN DRLAVYIDKV RSLETENSAL
QLQVTEREEV RGRELTGLKA LYETELADAR RALDDTARER AKLQIELGKF KAEHDQLVLN
YAKKESDLNG AQMKLREYEA ALNSKDAALA TALGDKKSLE GDLEDLKDQI AQLEASLAAA
KKQLADETLL KVDLENRCQS LTEDLEFRKN MYEEVVGMKN QFIVGFSMGL LMLENARLSS
EMNTSTVNSA REELMESRMR IESLSSQLSN LQKESRACLE RIQELEDLLA KERDNSRRML
SDKEREMAEI RDQMQQQLND YEQLLDVKLA LDMEISAYRK LLEGEEERLK LSPSPSSRVT
VSRASSSRSV RTTRGKRKRV DVEESEASSS VSISHSASAT GNVCIEEIDV DGKFIRLKNT
SEQDQPMGGW EMIRKIGDTS VSYKYTSRYV LKAGQTVTIW AANAGVTASP PTDLIWKNQN
SWGTGEDVKV ILKNSQGEEV AQRSTVFKTT IPEEEEDEED APEVLAEEEL FHQQGTTRAS
NRSCAIM
//
