ID A0A2U3XXQ7_LEPWE Unreviewed; 285 AA.
AC A0A2U3XXQ7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=cAMP-responsive element modulator {ECO:0000256|ARBA:ARBA00039496};
GN Name=CREM {ECO:0000313|RefSeq:XP_006736240.1,
GN ECO:0000313|RefSeq:XP_030886964.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006736240.1};
RN [1] {ECO:0000313|RefSeq:XP_006736240.1, ECO:0000313|RefSeq:XP_030886964.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006736240.1,
RC ECO:0000313|RefSeq:XP_030886964.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the bZIP family.
CC {ECO:0000256|ARBA:ARBA00007163}.
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DR RefSeq; XP_006736239.1; XM_006736176.1.
DR RefSeq; XP_006736240.1; XM_006736177.2.
DR RefSeq; XP_030886964.1; XM_031031104.1.
DR GeneID; 102746579; -.
DR CTD; 1390; -.
DR OrthoDB; 3137625at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd14690; bZIP_CREB1; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR003102; CREB1-like_pKID.
DR InterPro; IPR001630; Leuzip_CREB.
DR PANTHER; PTHR45879:SF4; CAMP-RESPONSIVE ELEMENT MODULATOR; 1.
DR PANTHER; PTHR45879; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR Pfam; PF02173; pKID; 1.
DR PRINTS; PR00041; LEUZIPPRCREB.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; Leucine zipper domain; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
DR PROSITE; PS50953; KID; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 104..163
FT /note="KID"
FT /evidence="ECO:0000259|PROSITE:PS50953"
FT DOMAIN 227..278
FT /note="BZIP"
FT /evidence="ECO:0000259|PROSITE:PS50217"
FT REGION 21..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 245..279
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 285 AA; 31254 MW; 6EB48850019B0E8A CRC64;
MSKCGRKKYI KTNLRQMTME TIESQQDGSV TDSVAESESA HTQTQTGQNS VPTLAQVSVA
GSGTGRGSPT VTLVQLPSGQ TVHVQGVIQT PQPSVIQSPQ IQTVQVATIA ETDESAESEG
VIDSHKRREI LSRRPSYRKI LNELSSDVPG VPKIEEEKPE EEGTPPNIAT MAVPTSIYQT
STGQYTATGD MPTYQIRAPT TALPQGVVMA ASPGSLHSPQ QLAEEATRKR ELRLMKNREA
ARECRRKKKE YVKCLENRVA VLENQNKTLI EELKALKDLY CHKAE
//
