ID A0A2U3XYQ4_LEPWE Unreviewed; 1129 AA.
AC A0A2U3XYQ4;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=WD repeat and HMG-box DNA-binding protein 1 isoform X1 {ECO:0000313|RefSeq:XP_006736518.1};
GN Name=WDHD1 {ECO:0000313|RefSeq:XP_006736518.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006736518.1};
RN [1] {ECO:0000313|RefSeq:XP_006736518.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006736518.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_006736518.1; XM_006736455.2.
DR AlphaFoldDB; A0A2U3XYQ4; -.
DR STRING; 9713.A0A2U3XYQ4; -.
DR GeneID; 102737282; -.
DR KEGG; lww:102737282; -.
DR CTD; 11169; -.
DR OrthoDB; 3686044at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd21993; HMG-box_WDHD1; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR048591; Ctf4-like_C.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR022100; Mcl1_mid.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19932; WD REPEAT AND HMG-BOX DNA BINDING PROTEIN; 1.
DR PANTHER; PTHR19932:SF10; WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1; 1.
DR Pfam; PF20946; Ctf4_C; 1.
DR Pfam; PF08662; eIF2A; 1.
DR Pfam; PF12341; Mcl1_mid; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00398; HMG; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267,
KW ECO:0000313|RefSeq:XP_006736518.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 9..41
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 132..173
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 230..267
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1015..1084
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 1015..1084
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 825..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1065..1129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..883
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..1001
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1002..1020
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1129 AA; 125952 MW; 2BCF8EAB53D62FBB CRC64;
MPAIQKPMRF GHTEGHTDVC FDDLGSYIVT CGSDGDVRIW EDLDDDDPKS INVGEKAYSC
ALKNGKLVTA VSNNTIQVHT FPEGVPDGIL TRFTTNANHV VFNGDGAKIA AGSSDFLVKV
VDVMDCSQQK TFRGHDAPVL SLSFDPKDIF LASASCDGTV KVWQISDQTC TVSWPLLQKC
NDVINAKSIC RLAWQPKSGK LLAVPVEKSV KLYRRETWNN QHDLSDNFIS QALNVVTWSP
CGQYLAAGSI NGLIIVWNVE TKDCMERVKH EKGYAICGLA WHPTCGRIAY TDAEGNLGLL
ENVCEPSGKT SSSKVSSRVE KDYNDLFEGD DTNNAGDFLN DNAVETPSFS KRIINDEEED
DDLMLASGHP RQRSHILEDD ENSVDVTMLK TGSSLLREEE EDDQADSIHN LPLVTSQRPF
YDGPMPTPRQ KPFQSGSTPM HLTHRFMVWN SVGIIRCYND EQDNAIDVEF HDTSIHHATH
LSNSLNYTVA DLSYEAVLLA CESTDELASK LHCLHFSSWD SSKEWIVDMP QNEDIEAICL
GLGWAAAATS AMLLRLFTIG GVQKELFSLP GPVVSMAGHG EQLFIAYHRG AGFDGDQCLG
VQLLELGKKK KQILHGEPLP LTRKSYLVWV GFSAEGTPCY TDSEGIVRML NRGLGNTWTP
ICNTREHCKG KSDHYWVVGI HENPQQLRCI PCKGSRFPPT LPRPAVAILS FKLPYCQIAT
EKGQMEEQFW RSIIFHNHLD YLAKNGYEYE ESTKNQAIKE QQELLMKMLA LSCKLDREFR
CVELADLMTQ NAVNLAIKYA SRSRRLILAQ RLSELAVEKA AELATTQVEE EEEEDFRKEL
NAGYSNTATE WSQPRLRNQV EEDAEDTREA DDKEEKPELH KHGQNLFSKS TNPSDVPAVK
SGAVTSSNQG RVNPFKVSSN SKEPATSMNS ARSSNILDSM NKSSKKSTAL NRATNNEKSP
VIKPLVPKPK SKQASAASYF QKRTSQTDKT EDVKEEHPKN SSSETPAMCP QNTENQRPKT
GFQMWLEENR SSILSDNPDF SDEADIIKEG MIRFRVLSAE ERKAWASKAK GGTTSDGAEA
KKRKHVVDES HETENEKEKA KENLNLPKKQ KPLDLSTNQK LSAFAFKQE
//