ID A0A2U3XZ84_LEPWE Unreviewed; 3064 AA.
AC A0A2U3XZ84;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=MAX gene-associated protein isoform X4 {ECO:0000313|RefSeq:XP_006736693.1};
GN Name=MGA {ECO:0000313|RefSeq:XP_006736693.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006736693.1};
RN [1] {ECO:0000313|RefSeq:XP_006736693.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006736693.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR RefSeq; XP_006736693.1; XM_006736630.2.
DR STRING; 9713.A0A2U3XZ84; -.
DR GeneID; 102745355; -.
DR KEGG; lww:102745355; -.
DR CTD; 23269; -.
DR OrthoDB; 5323209at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0071339; C:MLL1 complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18911; bHLHzip_MGA; 1.
DR CDD; cd20195; T-box_MGA-like; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR037935; MAX_gene-associated_bHLHzip.
DR InterPro; IPR032060; MGA_dom.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267:SF32; MAX GENE-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF16059; MGA_dom; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 79..260
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT DOMAIN 2422..2473
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 259..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 969..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1248..1329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1377..1428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1485..1514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1728..1753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1899..1923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1966..2045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2144..2163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2258..2314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2529..2558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2574..2593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2939..2966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1112..1143
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 262..276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1255..1282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1291..1308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1309..1325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1489..1511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1737..1753
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1969..1995
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1996..2015
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2020..2037
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2297..2314
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2543..2558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2576..2593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3064 AA; 335369 MW; 176E3C920D214103 CRC64;
MEEKQQIILA NQDGGTMAGA APTFFVILKQ PGNGKTDQGI LVTNRDACAL ASSVSSPGKS
KGKVCLPADC TVGGITVTLD NNSMWNEFYH RSTEMILTKQ GRRMFPYCRY WITGLDSNMK
YILVMDISPV DNHRYKWNGR WWEPSGKAEP HVLGRVFIHP ESPSTGHYWM HQPVSFYKLK
LTNNTLDQEG HIILHSMHRY LPRLHLVPAE KATEVIQLNG PGVHTFTFPQ TEFFAVTAYQ
NIQITQLKID YNPFAKGFRD DGLNSKPQRD GKQKNSSDQE GNSVPSSPGQ RVRLTEGEGS
EIQLTDSDPL SRGHETSGKC LEKPSLSIKR DFLGFMDIDS ALGEVPQLKQ EVSESLVANN
FEDGSHVVSP LDPNGNFNVV IKEEPVDDYE YELAECPEGV TIKQEETDEE TDVYSNSDDD
PILEKQLKRH NKVDNLEADH PSSKWLPNSP SGVAQAKMFK LDAGKMPVVY LEPCAVTKST
VKISELPDNM LSTSRKDKSS VLTELDYLPT YIENSNETGF CLGKESENGL RKHSPDLRVV
QKYPLLKEPQ WKYPELPDSI NTERIPDSSK SSAGDPFLGK EDLGRRRTTV LKISTASKVV
NANQNAPSNV PGKRGRPRKL KLSKAGRPPK NTGKSLTSTK NTPVGPGSTF PDVKPDLEDV
DGVLFVSFES KEALDIHAVD GTTEEPCSLQ ASTTNDPGCR ARISQLEKEL IEDLKALRHK
QVIHPGLQEV GLKLNSVDPT MSIDLKYLGV QLPLAPATSF PFWNLTGTNP ASPDAGFPFV
SRTGKTNDFT KIKGWRGKFH SASASRSEGG NSEGPLKNRS AFCSDKLDEY LENEGKLMET
SMGFSSNAPT SPVVYQLPTK STSYVRTLDS VLKKQSTVSP STSYSLKPHS VPPASRKAKS
QNKQATFGGR TKSSYKSILP YPVSPKQKHA HMIPGDKVAK NSSSTISENQ VNNFVVPTLD
ENTFPKQISL RQAHQQQQQQ QQGTRPPGLS KSQVKLMDLE DCALWEGKPR TYITEERADV
SLTTLLTAQA SLKTKPIHTI IRKRAPPCNN DFCRLGCVCS SLALEKRQPA HCRRPDCMFG
CTCLKRKVVL VKGGSKAKHF QRKAAHRDPV FYDALGEEQR EEEEGVREEE EQLKEKKRRK
KLEYTICETE PEQPVRHYPL WVKVEGEVDP EPVYIPTPSV IEPMKPLLLP QPEVLPTTVK
GKVLTGIKPA RAYTPKPNPV IREEDKDPVY LYFESMMTCA RVRVYERKKE EQRQPSPSPS
PSFQQQGSCQ SSPENCSVKE PDSEQQPLKP ITCDLEDDSD KSQEKSWKSS CNEGESSTSY
VHQRSPGGPT KLIEIISDCN WEEDRNKILS ILSQHINSNM PQSLKVGSFI IELASQRKSR
GEKNPPVYSS RVKISMPSCQ DQDDMAEKSG SETPDGPLSP GKMDDISPVQ TDALDSVRER
LHGGKGLPFY AGLSPAGKLV AYKRKPSSST SGLIQVASNA KVAASRKPRT LLPSTSNCKT
ASSSGATTNR PGKNLKAFVP AKRPIAARPS PGGVFTQFVM SKVGALQQKI PGVSTPQPLT
GPQKFSIRPS PVMVVTPVVS SEPVQVCSPV TAAVTTTTPQ VFLENVTAVT PMTAISDVGT
KETTYSSGAT TAGVVEVSET NTSTPVTPSQ STATVNLIKT TGITTPVASV AFPKSLVASP
PTITLPVAST ASTSIVVVTT AASSSMVTTP TSSLGSVPII LSGIDGSPPV SQRPENAPQI
PVATPQVSPN TVKRTGPRLL LIPVQQGSPT LRPVPNTQLQ GHRMVLQPVR SPSGMNLFRH
PNGQIVQLLP LHQLRGSNTQ PSLQPVMFRN PGSVMGIRLP TPSKPSETPP SSASSSAFSV
MNPVIQAVGS SPPVNVITQA PSLLSSGPSF VSQSGTLTLR ISPPEPQSFA SKTGSETKIT
YSSGGQPVGT ASLIPLQSGS FALLQLPGQK PVPSSILQHV ASLQMKRESQ SADQKDETSF
LKREQDTKKA LQSEGETIDS EANVIKQNSG ATASEEILHD SVGDGGDHLD EESLTEEGPI
TVKPSQHSYI TGSRIDEDYK DVDEEYGIRN HNSSKEKVTV LEVKTISKKA SNVTVQSISN
IQLKKLGDVK VEQQKGLENP EEKSSEFPII SKEGKLELSG SKVVEQQSLP QPEAKEKGCG
DSLEKDSIRE RWRKHLKGPL TQKCVGTSQE CKKEADEQLI KEIKTCQENS DVFQQEQGIS
DLLGKSGATE NVRVLKTECD SWSKISSPTA FSIVPRRATK GSRGEGHFQG HLLLSGEQIQ
PKQEKKGGRS SADLTVLDLE EEDEEDENEK TDDSIDEIVD VVSDYQSEEV DDVEKNNCVE
YIEDDEEQVD IETVEELSEE INVAHMKTTA AQTQTFKQPC RTHISADEKA AERSRKAPPI
PLKLKPDYWS EKLQKEAEAF AYYRRTHTAN ERRRRGEMRD LFEKLKITLG LLHSSKVSKS
LILTRAFSEI QGLTDQADKL IGQKNLLTRK RNVLIRKVSS LSGKTEEVVL KKLEYIYAKQ
QALEAQKRKK KMGSDEFDVS PRTSKQQEGS SASSVDLGQM FINNRKGKPL ILSRKRDQAT
ENTSPSNTPH TAANIVMTPQ GQLLTLKGPL FSGPVVTVSP ALLEADLKPQ VATSAVAQSE
NDDLFMMPRI VNVTSLATEG GLVDMGGSKY PHEVPDGKPS DHLKSTIRNE DNSFEDSGRI
SSRSNHRDGR MALGPTPVFL ANKDSGFPQI VDVSSMQEAQ EFLPKKISGE MRGIQYKWKE
CESRREKLKP KESAFHKLKM KDLKDSSIEM ELRKVASAIE EAALDPSELL TNMEDEDDTD
ETLTSLLNEI AFLNQQLNDD SVSLAELPSS MDTEFTGDAR RAFISKLPPG NRTTFQVGHL
GTGLKELPDV QGESDSVSPL LLHLEDDDFS ENEKQLAEPA SEPDVLKIVI DSEIKDSLLS
HRKASDGGKS TSGVPAEPES VSSPPVLHMK AGLENSSTDT LWRPMPKLAP LGLKVANPSS
DADGQSLKVM PSLAPVAAKV GLVGHKVNLT GNDQECRESK VMPTLAPVVA KLGNSGASPS
SAGK
//