ID A0A2U3XZJ6_LEPWE Unreviewed; 316 AA.
AC A0A2U3XZJ6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Epithelial cell adhesion molecule {ECO:0000256|ARBA:ARBA00015562};
DE AltName: Full=Tumor-associated calcium signal transducer 1 {ECO:0000256|ARBA:ARBA00031829};
GN Name=EPCAM {ECO:0000313|RefSeq:XP_006736887.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006736887.1};
RN [1] {ECO:0000313|RefSeq:XP_006736887.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006736887.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May act as a physical homophilic interaction molecule between
CC intestinal epithelial cells (IECs) and intraepithelial lymphocytes
CC (IELs) at the mucosal epithelium for providing immunological barrier as
CC a first line of defense against mucosal infection. Plays a role in
CC embryonic stem cells proliferation and differentiation. Up-regulates
CC the expression of FABP5, MYC and cyclins A and E.
CC {ECO:0000256|ARBA:ARBA00024978}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Lateral cell membrane {ECO:0000256|ARBA:ARBA00004591}; Single-pass type
CC I membrane protein {ECO:0000256|ARBA:ARBA00004591}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the EPCAM family.
CC {ECO:0000256|ARBA:ARBA00007669}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR RefSeq; XP_006736887.1; XM_006736824.2.
DR AlphaFoldDB; A0A2U3XZJ6; -.
DR STRING; 9713.A0A2U3XZJ6; -.
DR GeneID; 102739387; -.
DR KEGG; lww:102739387; -.
DR CTD; 4072; -.
DR OrthoDB; 5305981at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00191; TY; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR049420; EPCAM-Trop-2_C.
DR InterPro; IPR043406; EPCAM/Trop-2.
DR InterPro; IPR041630; EpCAM_N.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR14168:SF2; EPITHELIAL CELL ADHESION MOLECULE; 1.
DR PANTHER; PTHR14168; TUMOR-ASSOCIATED CALCIUM SIGNAL TRANSDUCER; 1.
DR Pfam; PF21283; EPCAM-Trop-2_C; 1.
DR Pfam; PF18635; EpCAM_N; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..316
FT /note="Epithelial cell adhesion molecule"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015408710"
FT TRANSMEM 268..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..137
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
SQ SEQUENCE 316 AA; 35568 MW; 13FBB1D4C082A96F CRC64;
MARSQVLAFG LLFAAATLAV AVAQKACVCE NYKLTTNCSW NTNGQCECTS LGAQNSVICS
KLATKCLVMK AEMTRSKSGR RVRPEGAFQN NDGLYDPDCD EKGLFKAKQC NGTTTCWCVN
TAGVRRTDKD NDDEISCSER VRTYWIIIEL KHKTRETPYD TKSLRTALMK TITTRYQLDP
KYITNILYEN DLITIDLMQN SSQKTQNDVD IADVAYYFEK DVKDESLFHS NRMDLRVNGE
QLDLDPGRTA IYYVDEKPPE FSMQGLQAGI IAVIVVVTLA VIAGIVVLVI SRKNRMAKYE
KAEIKEMGEM HRELNA
//
