ID A0A2U3Y1Y2_LEPWE Unreviewed; 359 AA.
AC A0A2U3Y1Y2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Doublesex- and mab-3-related transcription factor B1 {ECO:0000313|RefSeq:XP_006737737.1};
GN Name=DMRTB1 {ECO:0000313|RefSeq:XP_006737737.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006737737.1};
RN [1] {ECO:0000313|RefSeq:XP_006737737.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006737737.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00070}.
CC -!- SIMILARITY: Belongs to the DMRT family.
CC {ECO:0000256|ARBA:ARBA00006834}.
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DR RefSeq; XP_006737737.1; XM_006737674.2.
DR AlphaFoldDB; A0A2U3Y1Y2; -.
DR STRING; 9713.A0A2U3Y1Y2; -.
DR GeneID; 102726906; -.
DR KEGG; lww:102726906; -.
DR CTD; 63948; -.
DR OrthoDB; 5323333at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 4.10.1040.10; DM DNA-binding domain; 1.
DR InterPro; IPR001275; DM_DNA-bd.
DR InterPro; IPR036407; DM_DNA-bd_sf.
DR InterPro; IPR026607; DMRT.
DR PANTHER; PTHR12322; DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT; 1.
DR PANTHER; PTHR12322:SF66; DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR B1; 1.
DR Pfam; PF00751; DM; 1.
DR SMART; SM00301; DM; 1.
DR SUPFAM; SSF82927; Cysteine-rich DNA binding domain, (DM domain); 1.
DR PROSITE; PS40000; DM_1; 1.
DR PROSITE; PS50809; DM_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00070};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00070};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00070}; Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00070}.
FT DOMAIN 18..65
FT /note="DM"
FT /evidence="ECO:0000259|PROSITE:PS50809"
FT DNA_BIND 18..65
FT /note="DM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00070"
FT REGION 265..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..294
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..318
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 359 AA; 38180 MW; EE02F7898DEB853E CRC64;
MKADPAKLAD KMLRSPKCSR CRNHGFLVPV KGHAGKCRWK QCTCEKCSLI TERQKIMAAQ
KVLKKQASEE EQEMALGAHR PELLSGAAAA APGSSLRQLL PLAVSGDREV GPECRVPAGF
PERPPRGPSP GPSAFQPVLG GRGHVGLSER ATVAVPSSVG LQLGAEAAGK GYSGRLELRR
PLRPVPSPPF ADFGLSLSIS SDCVVGSEYL EREPSKLYPS CSNMHSYCPF PLGYQDGSPT
PGIPLQRGFR HVSCSHFHGG ALVPEPVGDF QPSYYPPPPP PPPPPPPAPQ PQFLPPGFLS
ALHFLPPLPP PPPPASFSLA VPSDTDKETA DNQDQDQDAE GPEAPPREPS QPSSQEPSD
//
