ID   A0A2U3Y2Y2_LEPWE        Unreviewed;       324 AA.
AC   A0A2U3Y2Y2;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Protein FAM49B isoform X2 {ECO:0000313|RefSeq:XP_006738092.1, ECO:0000313|RefSeq:XP_030889106.1};
GN   Name=FAM49B {ECO:0000313|RefSeq:XP_006738092.1,
GN   ECO:0000313|RefSeq:XP_030889106.1, ECO:0000313|RefSeq:XP_030889107.1};
OS   Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC   Leptonychotes.
OX   NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006738092.1};
RN   [1] {ECO:0000313|RefSeq:XP_006738092.1, ECO:0000313|RefSeq:XP_030889106.1}
RP   IDENTIFICATION.
RC   TISSUE=Liver {ECO:0000313|RefSeq:XP_006738092.1,
RC   ECO:0000313|RefSeq:XP_030889106.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBUNIT: Interacts with RAC1 (GTP-bound form preferentially).
CC       {ECO:0000256|ARBA:ARBA00011307}.
CC   -!- SIMILARITY: Belongs to the CYRI family.
CC       {ECO:0000256|ARBA:ARBA00005778}.
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DR   RefSeq; XP_006738092.1; XM_006738029.2.
DR   RefSeq; XP_030889106.1; XM_031033246.1.
DR   RefSeq; XP_030889107.1; XM_031033247.1.
DR   STRING; 9713.A0A2U3Y2Y2; -.
DR   GeneID; 102742505; -.
DR   CTD; 51571; -.
DR   OrthoDB; 2785093at2759; -.
DR   Proteomes; UP000245341; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   InterPro; IPR039789; CYRI.
DR   InterPro; IPR009828; CYRIA/CYRIB_Rac1-bd.
DR   PANTHER; PTHR12422:SF3; CYFIP-RELATED RAC1 INTERACTOR B; 1.
DR   PANTHER; PTHR12422; UNCHARACTERIZED; 1.
DR   Pfam; PF07159; CYRIA-B_Rac1-bd; 1.
PE   3: Inferred from homology;
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245341}.
FT   DOMAIN          19..320
FT                   /note="CYRIA/CYRIB Rac1 binding"
FT                   /evidence="ECO:0000259|Pfam:PF07159"
SQ   SEQUENCE   324 AA;  36793 MW;  FFDD6C779E16EEFB CRC64;
     MGNLIKVLTR DIDHNAAHFF LDFENAQPTE SEKEIYNQVN VVLKDAEGIL EDLQSYRGAG
     HEIREAIQHP ADEKLQEKAW GAVVPLVGKL KTFYEFSQRL EAALRGLLGA LTSTPYSPTQ
     HLEREQALAK QFAEILHFTL RFDELKMTNP AIQNDFSYYR RTLSRMRINN VPAEGENEVN
     NELANRMSLF YAEATPMLKT LSDATTKFVS ENKNLPIENT TDCLSTMASV CRVMLETPEY
     RSRFTNEETV SFCLRVMVGV IILYDHVHPV GAFAKTSKID MKGCIKVLKD QPPNSVEGLL
     NALRYTTKHL NDETTSKQIK SMLQ
//