ID A0A2U3Y650_LEPWE Unreviewed; 746 AA.
AC A0A2U3Y650;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Testis anion transporter 1 {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 8 {ECO:0000256|RuleBase:RU362052};
GN Name=SLC26A8 {ECO:0000313|RefSeq:XP_006739189.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006739189.1};
RN [1] {ECO:0000313|RefSeq:XP_006739189.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006739189.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362052}.
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DR RefSeq; XP_006739189.1; XM_006739126.2.
DR AlphaFoldDB; A0A2U3Y650; -.
DR STRING; 9713.A0A2U3Y650; -.
DR GeneID; 102749585; -.
DR KEGG; lww:102749585; -.
DR CTD; 116369; -.
DR OrthoDB; 1067648at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0098661; P:inorganic anion transmembrane transport; IEA:UniProtKB-UniRule.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR PANTHER; PTHR11814:SF11; TESTIS ANION TRANSPORTER 1; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|RuleBase:RU362052};
KW Differentiation {ECO:0000256|RuleBase:RU362052};
KW Meiosis {ECO:0000256|RuleBase:RU362052};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Spermatogenesis {ECO:0000256|RuleBase:RU362052};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 135..153
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 266..295
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 321..574
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 61..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..696
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 746 AA; 83745 MW; 4C142C5F4F61CF14 CRC64;
MAQVKGLPRP GYPHLQAPHR CCPCCRSSPE LRSPAHHNAR GFGLNGSGTA GVRVYSAASR
ARAASDPSAR TRAPAGNQVE PRPGAAGGRA PQILGFTAFA NKISMATETS RMLIDMIPYS
FLFPVMPDLN ILPELILEAF SLALVSSSLL IFLGKKIANY HNYHVNSNQD LIAIGLCNVI
SSFFRSCVFT GAIIRTIIQD KSGGRQQFAS LVGAGVMLLL MVKVGRFFHE MPNAVLAGII
LSNILPYFET IYNLPSLWRQ NQYDCVIWLV TFISAIFLGL DVGLLVSVAF AFFIITVRSH
RTKILLLGQI PNTNIYRSFS DYREVTNLPG VKIFQCCNSI TFVNVNHLKH KLLKEVEMVR
VPLKEEEVFR LFNQSEEGSR EEKICQCFCN CDEVELSPRV VYTERFESKQ DQDSSSINLI
RCSRFESMNM SQSTSNEQVP YTVSSMSHRN PGPNYEAVDK AWLSNNPSRN SSMPLPGIAE
NQGRDRSFLP FSDISLLPSI HTIILDFSMV HFVDPQASVV LRQMCNAFQN ANILVLISGC
HSSVVRAFER NDFFDAGITK AQLFLTLHDA VLFALSRKFP ESSELSMDES ETVIQETYSE
TDKNGESGHK MNRSLLDVSK NINPDYTMVQ EPITGEELEL DLELEPTLES EQEAGLDLEL
DLDHEMEPES ELEPESELEP ELELKPESES KPRPRAHTYP RQQYWPLYQS MPPSSPSQDR
PRTQSLERRR QHKNSYSPKG NKTVDP
//