ID A0A2U3Y8Z2_LEPWE Unreviewed; 285 AA.
AC A0A2U3Y8Z2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Homeobox protein Hox-B13 {ECO:0000313|RefSeq:XP_006740078.1};
GN Name=HOXB13 {ECO:0000313|RefSeq:XP_006740078.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006740078.1};
RN [1] {ECO:0000313|RefSeq:XP_006740078.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006740078.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family.
CC {ECO:0000256|ARBA:ARBA00006317}.
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DR RefSeq; XP_006740078.1; XM_006740015.1.
DR AlphaFoldDB; A0A2U3Y8Z2; -.
DR STRING; 9713.A0A2U3Y8Z2; -.
DR GeneID; 102737206; -.
DR KEGG; lww:102737206; -.
DR CTD; 10481; -.
DR OrthoDB; 728401at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR022067; HoxA13_N.
DR PANTHER; PTHR45804:SF6; HOMEOBOX PROTEIN HOX-B13; 1.
DR PANTHER; PTHR45804; SEGMENTATION PROTEIN FUSHI TARAZU-LIKE PROTEIN; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF12284; HoxA13_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000245341}.
FT DOMAIN 215..275
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 217..276
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 50..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 285 AA; 30729 MW; 019007B90A502B9C CRC64;
MEPGSYAALD GAKDLEVLPG AGGSRHLVAH CPPTGHPAVA PTLMPAVSHA PLDLPGSAEP
PKQCQPCPGL PQGAAPAPVP YGYFGGGYYS CRVSRSSLKP CAQAAPLAAY SAETATAGEQ
YPSRPTEFAF YPGYPGPYQP MASYLDVSVV QTLGAPGEPR HESLLPVDSY QPWALTGGWN
GQMCCQGEQN PPGPFWKAAF AESGTQHPPD GCTFRRGRKK RIPYSKGQLR ELEREYSANK
FITKDKRRKI SAATSLSERQ ITIWFQNRRV KEKKVLAKVK TSTTP
//
