ID A0A2U3YDJ3_LEPWE Unreviewed; 735 AA.
AC A0A2U3YDJ3;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Zinc transporter ZIP6 {ECO:0000256|ARBA:ARBA00039393};
DE AltName: Full=Solute carrier family 39 member 6 {ECO:0000256|ARBA:ARBA00042779};
DE AltName: Full=Zrt- and Irt-like protein 6 {ECO:0000256|ARBA:ARBA00041704};
GN Name=SLC39A6 {ECO:0000313|RefSeq:XP_006741805.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006741805.1};
RN [1] {ECO:0000313|RefSeq:XP_006741805.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006741805.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_006741805.1; XM_006741742.1.
DR AlphaFoldDB; A0A2U3YDJ3; -.
DR STRING; 9713.A0A2U3YDJ3; -.
DR GeneID; 102750836; -.
DR KEGG; lww:102750836; -.
DR CTD; 25800; -.
DR OrthoDB; 5488029at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR PANTHER; PTHR12191:SF22; ZINC TRANSPORTER ZIP6; 1.
DR Pfam; PF02535; Zip; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..735
FT /note="Zinc transporter ZIP6"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015675884"
FT TRANSMEM 303..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 665..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 704..725
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 95..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..478
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 735 AA; 82579 MW; 2684E1B3D5482F34 CRC64;
MARNLSVILI LTFTLSVTNP LHELEPATAF AQTTEKIITN WESGINVDLA VATRRHHLQQ
LFHRYGENNS LSVEGFRKLL QNIGIDKVKK IHIHHDHDHH SDHDHHSHRN HPASSKNNRK
ALCPDHESDS LGKDPRNSQG KGSHRSERAN GRRNVLIKDG VTASEVTSAV YNAVSEGTHF
LETIDTPKPG KFFPKDVSSS TPPSITEKSR VSRLASRKTN ESVSEPRKGF MYSRNANENT
QECFNASKLL TSHGMGIQVL LNATEFNYLC PAIINQIDAR SCLIHTTSEK KAEIPPKTYS
LQIAWVGGFI AISIISFLSL LGVILVPLMN RVFFKFLLSF LVALAVGTLS GDAFLHLLPH
SHASHHHSHS HEESTVEMKR GPLFSHLSSQ NIEESTYFDS TWKGLTALGG LYFMFLVEHV
LTLIKQFKDK KKKNQKKPET DDDVEIKKQL SKYESQLSTN EEKVDADDRP EGYLRTDSQE
PSHFDSQQPA ILEEEEVMIA HAHPQEVYNE YVPRGCKNKC HSHFHDTLGQ SDDLIHHHHD
YHHILHHHHH QNHHPHSHSQ RYSREELKDA GIATLAWMVI MGDGLHNFSD GLAIGAAFTE
GLSSGLSTSV AVFCHELPHE LGDFAVLLKA GMTVKQAVLY NALSAMLAYL GMATGIFIGH
YAENVSMWIF ALTAGLFMYV ALVDMVPEML HNDASDHGCS RWGYFFLQNA GILLGFGIML
LISIFEHKIV FRINF
//