ID   A0A2U3YE90_LEPWE        Unreviewed;       188 AA.
AC   A0A2U3YE90;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Calcium load-activated calcium channel {ECO:0000256|ARBA:ARBA00014950, ECO:0000256|PIRNR:PIRNR023322};
DE            Short=CLAC channel {ECO:0000256|PIRNR:PIRNR023322};
GN   Name=TMCO1 {ECO:0000313|RefSeq:XP_006742055.1};
OS   Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC   Leptonychotes.
OX   NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006742055.1};
RN   [1] {ECO:0000313|RefSeq:XP_006742055.1}
RP   IDENTIFICATION.
RC   TISSUE=Liver {ECO:0000313|RefSeq:XP_006742055.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Calcium-selective channel required to prevent calcium stores
CC       from overfilling. {ECO:0000256|PIRNR:PIRNR023322}.
CC   -!- SUBUNIT: Homodimer and homotetramer. Homodimer under resting
CC       conditions; forms homotetramers following and ER calcium overload.
CC       {ECO:0000256|PIRNR:PIRNR023322}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TMCO1 family.
CC       {ECO:0000256|ARBA:ARBA00006537, ECO:0000256|PIRNR:PIRNR023322}.
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DR   RefSeq; XP_006742055.1; XM_006741992.2.
DR   AlphaFoldDB; A0A2U3YE90; -.
DR   SMR; A0A2U3YE90; -.
DR   STRING; 9713.A0A2U3YE90; -.
DR   GeneID; 102728759; -.
DR   KEGG; lww:102728759; -.
DR   CTD; 54499; -.
DR   OrthoDB; 313692at2759; -.
DR   Proteomes; UP000245341; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IEA:UniProtKB-UniRule.
DR   InterPro; IPR002809; EMC3/TMCO1.
DR   InterPro; IPR008559; TMCO1.
DR   PANTHER; PTHR20917:SF0; CALCIUM LOAD-ACTIVATED CALCIUM CHANNEL; 1.
DR   PANTHER; PTHR20917; PNAS-RELATED; 1.
DR   Pfam; PF01956; EMC3_TMCO1; 1.
DR   PIRSF; PIRSF023322; DUF841_euk; 1.
DR   SMART; SM01415; DUF106; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRNR:PIRNR023322};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW   ECO:0000256|PIRNR:PIRNR023322};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR023322};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|PIRNR:PIRNR023322};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR023322};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR023322}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..188
FT                   /note="Calcium load-activated calcium channel"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015601708"
FT   TRANSMEM        6..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        91..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   COILED          33..89
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   188 AA;  21175 MW;  FB77BFC4F0629EB1 CRC64;
     MSTMFADTLL IVFISVCTAL LAEGITWVLV YRTDKYKRLK AEVEKQSKKL EKKKETITES
     AGRQQKKKIE RQEEKLKNNN RDLSMVRMKS MFAIGFCFTA LMGMFNSIFD GRVVAKLPFT
     PLSYIQGLSH RNLLGDDTTD CSFIFLYILC TMSIRQNIQK ILGLAPSRAA TKQAGGFLGP
     PPPSGKFS
//