ID A0A2U3YF81_LEPWE Unreviewed; 370 AA.
AC A0A2U3YF81;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Leucine-rich repeat and transmembrane domain-containing protein 2 isoform X1 {ECO:0000313|RefSeq:XP_006742380.1, ECO:0000313|RefSeq:XP_030893805.1};
GN Name=LRTM2 {ECO:0000313|RefSeq:XP_006742380.1,
GN ECO:0000313|RefSeq:XP_030893805.1, ECO:0000313|RefSeq:XP_030893806.1,
GN ECO:0000313|RefSeq:XP_030893807.1, ECO:0000313|RefSeq:XP_030893808.1,
GN ECO:0000313|RefSeq:XP_030893809.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006742380.1};
RN [1] {ECO:0000313|RefSeq:XP_006742380.1, ECO:0000313|RefSeq:XP_030893805.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006742380.1,
RC ECO:0000313|RefSeq:XP_030893805.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_006742380.1; XM_006742317.2.
DR RefSeq; XP_030893805.1; XM_031037945.1.
DR RefSeq; XP_030893806.1; XM_031037946.1.
DR RefSeq; XP_030893807.1; XM_031037947.1.
DR RefSeq; XP_030893808.1; XM_031037948.1.
DR RefSeq; XP_030893809.1; XM_031037949.1.
DR STRING; 9713.A0A2U3YF81; -.
DR GeneID; 102736598; -.
DR KEGG; lww:102736598; -.
DR CTD; 654429; -.
DR OrthoDB; 4193933at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF175; LEUCINE RICH REPEATS AND TRANSMEMBRANE DOMAINS 2; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01462; LRRNT; 1.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|RefSeq:XP_006742380.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 307..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..72
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
FT DOMAIN 198..251
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 261..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..288
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 370 AA; 41268 MW; 46EB8D6F7979CDB7 CRC64;
MLARGSGPEQ RSRLALQWRQ ISWITCWIML YAVEALPACP FSCKCDSRSL EVDCSGLGLT
MVPPDLPAAT RTLLLLNNKL SALPSWAFAN LSSLQRLDLS NNFLDQLPRS LFGDLTNLTE
LQLRNNSIRT LDRDLLQHSP LLRHLDLSIN GLAQLPPGLF DGLPALRSLS LRSNRLQNLD
RLTFEPLASL QLLQVGDNPW ECDCNLRDFK HWMEWFSYRG GRLDQLACTL PKELRGKDMR
VVPMEMFNYC SQLEDENSSA GLDIPGPPCT KASPEPAKPK PGAEPEPEPS TACPQKQRYR
PVSVRRAIGT VIIAGVVCGI VCIMMVVAAA YGCIYASVMA KYHRELKKRQ PLMGDPEGEH
EDQKQISSVA
//
