ID   A0A2U3YGX6_LEPWE        Unreviewed;      1091 AA.
AC   A0A2U3YGX6;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   Name=STK36 {ECO:0000313|RefSeq:XP_006742970.1};
OS   Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC   Leptonychotes.
OX   NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006742970.1};
RN   [1] {ECO:0000313|RefSeq:XP_006742970.1}
RP   IDENTIFICATION.
RC   TISSUE=Liver {ECO:0000313|RefSeq:XP_006742970.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR   RefSeq; XP_006742970.1; XM_006742907.2.
DR   AlphaFoldDB; A0A2U3YGX6; -.
DR   STRING; 9713.A0A2U3YGX6; -.
DR   GeneID; 102727540; -.
DR   KEGG; lww:102727540; -.
DR   CTD; 27148; -.
DR   OrthoDB; 275383at2759; -.
DR   Proteomes; UP000245341; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   PANTHER; PTHR22983; PROTEIN KINASE RELATED; 1.
DR   PANTHER; PTHR22983:SF6; SERINE_THREONINE-PROTEIN KINASE 36; 1.
DR   Pfam; PF13646; HEAT_2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_006742970.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   REGION          86..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..100
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1091 AA;  118526 MW;  C0CC4E81A5E630B2 CRC64;
     MIVKSFLQGL LTKDPRQRLS WPDLLHHPFI AGRVTIITEP GGPDLGTPFT SRLPPELQVL
     KDQQVHQLAP KGNRSRILRQ ACKRMAEEAK QKKHQNTGPA LEQEDRTSKM ASGTAPLPRL
     RATPQEPGLL AGILASEMKS SWAEWGAGEA PPAPRENQIT QDCERVLPEL RPEVVGQRSI
     DAVDLENEEP DSDDEWQHLL ETTEPVPIQL KAPLTLLCNP DFCQRIQGQL HEAGGQILKG
     MLEGASRILP ALRVLSSLLS SCSDSIPLYS FCREAGLPGL LLSLLRHSQE CDSIQQQCWY
     GTFSRDLMAV IQAYFACTFN LERSQTGDSL QVFQEAANLF LDLLGKLLAQ PDDSEQTLRR
     DSLMCFTVLC EAMDGNSWSV SKAFYSSLLT TQRAVLDGLL HSLTVPQLPF HTPPGAPQVS
     QPLREQSEDL PGAMSSALAA VCTAPVGLPS CWEAKEQISQ HLAHQLTEDS NQLRPSLISG
     LQHPILCLHL LKVLYSCCHV SERLCHLLGH EPLALESLLM LVQGKVKVMD WEESTEVALY
     LLSLLVLRLQ DLPSGMEKLG NEIATLFTHS HIVSLVSAAA CLLGQLGQQG VTFDLQPVEW
     IAAASHALSA PAEVRLTPPG SCGFYDGLLI LLLHLLTQPG KGSLIRDVVS SEMWTVLWHR
     FSMALRLPEV VSPQEEEPSL SRPQNPEPDW TLISPQGVAA LLSLAVATFT QEPQLCLSHL
     SQRGSILMST LKHLLSPSFL HQLGRAPHGS EFLPLVVLSV CRLLCFPFAL DVDDDLLGGV
     LADFGVSEVA AHLLQVCCHH LPLPQVELPV SLLTRLALTD PTSLNQFVTA VAASPRPVIS
     FLSVALLGDQ PLLTSDLLSL LAHTARVLSP SHLSFIQELL AGSDESYRPL RSLLGHPENS
     VRARTYGLLG HLLQHSMALR GALQSQAGLL SLLLVGLGDK DPAVRRSATF AVGNAAYQAG
     PLGPALAAAV PGMTQLLRDP QAGIRRNAAS ALGNLGPEGL GAELLQCQVP QRLLEMACGD
     PQLNVKEAAL IALRSLRQEP CIHQVLVSLG ASERLAMLSL GNQLLAPSSP RPASARHCRK
     LIHLLRPTHS T
//