ID A0A2U3YI95_LEPWE Unreviewed; 736 AA.
AC A0A2U3YI95;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Leucine-rich repeat and calponin homology domain-containing protein 1 isoform X5 {ECO:0000313|RefSeq:XP_006743313.1};
GN Name=LRCH1 {ECO:0000313|RefSeq:XP_006743313.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006743313.1};
RN [1] {ECO:0000313|RefSeq:XP_006743313.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006743313.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_006743313.1; XM_006743250.2.
DR AlphaFoldDB; A0A2U3YI95; -.
DR GeneID; 102742421; -.
DR CTD; 23143; -.
DR OrthoDB; 2956716at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd21270; CH_LRCH1; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF4; LEUCINE RICH REPEATS AND CALPONIN HOMOLOGY DOMAIN CONTAINING 1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00033; CH; 1.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 5.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 711..729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 584..700
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 21..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..40
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 736 AA; 81962 MW; 2B661B2C2ADDD95E CRC64;
MATPGSEPQP FVPALSVATL HPHHHPHHHH HHHHHHQHHG GTGASSGVGG GGGGGGGGSG
GFNLPLNRGL ERALEEAANS GGLNLSARKL KEFPRTAAPG HDLSDTVQAD LSKNRLVEVP
MELCHFVSLE ILNLYHNCIR VIPEAIINLQ MLTYLNLSRN QLSALPACLC GLPLKVLIAS
NNKLGSLPEE IGQLKQLMEL DVSCNEITAL PQQIGQLKSL RELNVRRNYL KVLPQELVDL
PLVKFDFSCN KVLVIPICFR QMKQLQVLLL ENNPLQSPPA QICTKGKVHI FKYLSIQACQ
IKTADSLDLH TMERPHFHQH VEDSKKDSDS GVGSDNGDKR LSATEPSDED AVSLNVPMSN
IMEEEQIVKE DSCHRLSPVK GDSHQEFQPE PSLLGDNDNS GEERDQFTDG TDVLRSEFIT
YIKDRAEDCE ELLRIEEDTH WQPEGIISSS KDQDMDIVMI DQLREAVDLL QDPNRLNTDI
TERNVVNFYP VESAEALDLQ DSALNGQIQL ETSPVCEVQN DLTSQSNGSE YSPNEMRANS
PAISPTTNST TPFGLKPRSV FLRPQRNLES IDPQFTIRRK MEQMREEKEL VEQLRESIEM
RLKVSLHEDL GAALMDGVVL CHLVNHIRPR SVASIHVPSP AVPKLSMAKC RRNVENFLEA
CRKLGVPEAD LCSSYDILQS DFHHVRKTVD TLLALGEKPP QPTSALRSRD LISFCLVHIL
FIVLIYVTYH WNALSA
//
