ID   A0A2U3YK08_LEPWE        Unreviewed;       955 AA.
AC   A0A2U3YK08;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=ADAMTS-like protein 2 isoform X1 {ECO:0000313|RefSeq:XP_006744060.1};
GN   Name=ADAMTSL2 {ECO:0000313|RefSeq:XP_006744060.1};
OS   Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC   Leptonychotes.
OX   NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006744060.1};
RN   [1] {ECO:0000313|RefSeq:XP_006744060.1}
RP   IDENTIFICATION.
RC   TISSUE=Liver {ECO:0000313|RefSeq:XP_006744060.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_006744060.1; XM_006743997.2.
DR   AlphaFoldDB; A0A2U3YK08; -.
DR   STRING; 9713.A0A2U3YK08; -.
DR   GeneID; 102730673; -.
DR   KEGG; lww:102730673; -.
DR   CTD; 9719; -.
DR   OrthoDB; 2910701at2759; -.
DR   Proteomes; UP000245341; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR   Gene3D; 2.60.120.830; -; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR   InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR   InterPro; IPR045371; ADAMTS_CR_3.
DR   InterPro; IPR010294; ADAMTS_spacer1.
DR   InterPro; IPR010909; PLAC.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR   PANTHER; PTHR13723:SF281; NO LONG NERVE CORD, ISOFORM C; 1.
DR   Pfam; PF19236; ADAMTS_CR_3; 1.
DR   Pfam; PF05986; ADAMTS_spacer1; 1.
DR   Pfam; PF08686; PLAC; 1.
DR   Pfam; PF19030; TSP1_ADAMTS; 4.
DR   Pfam; PF00090; TSP_1; 1.
DR   PRINTS; PR01857; ADAMTSFAMILY.
DR   SMART; SM00209; TSP1; 7.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 7.
DR   PROSITE; PS50900; PLAC; 1.
DR   PROSITE; PS50092; TSP1; 5.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR613273-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..955
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015719987"
FT   DOMAIN          916..954
FT                   /note="PLAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50900"
FT   REGION          534..561
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        59..100
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT   DISULFID        63..105
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT   DISULFID        74..90
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
SQ   SEQUENCE   955 AA;  104926 MW;  9455EF89E2783796 CRC64;
     MDGRRQPSRW VWCLLAVALL AGGVASTGAT DNSPTSNSLE GGTDATAYWW GEWTKWTACS
     RSCGVGVTSQ ERHCLQQRRT SVTGAGNRTC TGTSKRYQLC RVQECPPDGR SFREEQCISF
     NSRVYDGRTH QWKPLYPDDY VHISSKPCDL HCTTVDGQRQ LMVPARDGTS CKLTDLRGVC
     VSGKCEPIGC DGVLFSTHTL DKCGVCQGDG SSCTHVTGNY RKGNVHLGYS LVTHIPAGAR
     DIQIVERKKS AGVLALADEA GYYFFNGNFK VDSPKNFNIA GTVVKYRRPM DVYETGIEYI
     VAQGPTNQGL NVMVWNQNGK SPSITFEYTL LQPPHAHRIQ PVYYSFSEPA SESAESQELD
     GAALLGFLRH NGSFYGQASS ERLGLDNRVF GHLGPGIELG LSKGQETNEV CEQAGGRACE
     GPPRGKGFRD GNATGTALAG DKDDQEVDAR LTSQRLLSAN VISDQLLGAG SDSRELPFNE
     TGNSIFVQGA PRSSPAESLY VDYEENEGVG AYLLNGSYLE LSNDRVTNTS SEAPFPNASA
     SLPAMAGNRT HKARTRPKAR KQGVSPADMY RWKLSSHEPC SSTCTTGVMS TYAMCVRYDG
     IEVDDSYCDA LTRPEPVQEF CAGRECQPRW ETSSWSECSR TCGEGYQFRI VRCWKMLSPG
     FDSSVYSDLC EAAEAVRPEE RKTCRNPACG PQWEMSEWSE CTAKCGERSV VTRDIRCSED
     EKLCDPNTRP VGEKDCTGPP CDRQWTVSDW GPCSGSCGQG RMIRHVYCKT SDGRVVPESQ
     CQTETKPLAI HPCGDKNCPA HWLAQDWERC NTTCGRGVKK RLVLCMELAN GKPQTRSGPE
     CGLAKKPPEE STCFERPCFK WYTSPWSECT KTCGVGVRMR DVKCYQGTDI VRGCDPLVKP
     VGRQACDLQP CPTEPPDDSC QDQPGTNCAL AIKVNLCGHW YYSKACCRSC RPPHS
//