ID A0A2U3YMM3_LEPWE Unreviewed; 387 AA.
AC A0A2U3YMM3;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=G-protein coupled receptor family C group 5 member B {ECO:0000313|RefSeq:XP_006744980.1, ECO:0000313|RefSeq:XP_030896722.1};
GN Name=GPRC5B {ECO:0000313|RefSeq:XP_006744980.1,
GN ECO:0000313|RefSeq:XP_030896722.1, ECO:0000313|RefSeq:XP_030896723.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006744980.1};
RN [1] {ECO:0000313|RefSeq:XP_006744980.1, ECO:0000313|RefSeq:XP_030896722.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006744980.1,
RC ECO:0000313|RefSeq:XP_030896722.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_006744980.1; XM_006744917.2.
DR RefSeq; XP_030896722.1; XM_031040862.1.
DR RefSeq; XP_030896723.1; XM_031040863.1.
DR STRING; 9713.A0A2U3YMM3; -.
DR GeneID; 102745387; -.
DR KEGG; lww:102745387; -.
DR CTD; 51704; -.
DR OrthoDB; 4263681at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15278; 7tmC_RAIG2_GPRC5B; 1.
DR InterPro; IPR017978; GPCR_3_C.
DR PANTHER; PTHR14511; G PROTEIN COUPLED RECEPTOR, CLASS C, GROUP 5; 1.
DR PANTHER; PTHR14511:SF9; G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 5 MEMBER B; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_006744980.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..387
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041068147"
FT TRANSMEM 46..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 87..247
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 387 AA; 42958 MW; B890AE4AD0179F6D CRC64;
MKTHHVLAFL LLFMIASGAS ENASTSRGCG LDLLPQYVSL CDLDTIWGIV VEAVAGAGAL
ITLLLMLILL VRLPFIKDKE KKDPVGLHFL FLLGTLGLFG LTFAFIIRED ETICAVRRFL
WGVLFALCFS CLLSQAWRVR RLVRHGKSPS GWQLVGVALC LMLVQVIIAI EWLVLTVLRD
AKPACAYEPM DFVMALIYDM VLLVAALGLA LFTLCGKFKK WKQNGACVLV TAFLSVLIWV
AWMTMYLFGN AELRQGDAWG DPTLAITLVA SGWVFVIFHA IPEIHCTILP APQENTPNYF
DTSQPRMRET AFEEDVPLPR TYMENKAFSM DEHNAALRTA GFRNGSLGNR PSAPFRSNVY
QPTEMAVVLN GGTIPTAPPS YTGRHLW
//
