ID A0A2U3YNY9_LEPWE Unreviewed; 840 AA.
AC A0A2U3YNY9;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN Name=GRIN2D {ECO:0000313|RefSeq:XP_006745446.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006745446.1};
RN [1] {ECO:0000313|RefSeq:XP_006745446.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006745446.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR RefSeq; XP_006745446.1; XM_006745383.1.
DR AlphaFoldDB; A0A2U3YNY9; -.
DR STRING; 9713.A0A2U3YNY9; -.
DR GeneID; 102748893; -.
DR KEGG; lww:102748893; -.
DR CTD; 2906; -.
DR OrthoDB; 1034721at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022824; F:transmitter-gated monoatomic ion channel activity; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR CDD; cd13718; PBP2_iGluR_NMDA_Nr2; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF385; GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT TRANSMEM 496..519
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 569..594
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 758..777
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 343..738
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 386..442
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_006745446.1"
SQ SEQUENCE 840 AA; 93040 MW; 2552835A8E792EC0 CRC64;
LVLNGSDPRS LVLQLCDLLS GLRVHGVVFE DDSRAPAVAP ILDFLSAQTS LPIVAVHGGA
ALVLTPKEKG STFLQLGSST EQQLQVIFEV LEEYDWTSFV AVTTRAPGHR AFLSYIEVLT
DGSMVGWEHR GALTLDPGAG EAVLGAQLRS VSAQIRLLFC AREEAEPVFR AAEEAGLTGP
GYVWFMVGPQ LAGGGGSGAP GEPPLLPGGA PLPAGLFAVR SAGWRDDLAR RVAAGVAVVA
RGAQALLRDY GFLPELGHDC RAQNRTHRGE SLHRYFMNIT WDNRDYSFNE DGFLVNPSLV
VISLTRDRTW EVVGSWEQQT LRLKYPLWSR YGRFLQPVDD TQHLTVATLE ERPFVIVEPA
DPISGTCIRD SVPCRSQLNR THSPPPDAPR PEKRCCKGFC IDILKRLAQT IGFSYDLYLV
TNGKHGKKID GVWNGMIGEV FYQRADMAIG SLTINEERSE IVDFSVPFVE TGISVMVARS
NGTVSPSAFL EPYSPAVWVM MFVMCLTVVA VTVFIFEYLS PVGYNRSLAT GKRPGGSTFT
IGKSIWLLWA LVFNNSVPVE NPRGTTSKIM VLVWAFFAVI FLASYTANLA AFMIQEEYVD
TVSGLSDRKF QRPQEQYPPL KFGTVPNGST EKNIRSNYPD MHSYMVRYNQ PRVEEALTQL
KAGKLDAFIY DAAVLNYMAR KDEGCKLVTI GSGKVFATTG YGIALHKGSR WKRPIDLALL
QFLGDDEIEM LERLWLSGIC HNDKIEVMSS KLDIDNMAGV FYMLLVAMGL SLLVFAWEHL
VYWRLRHCLG PTHRMDFLLA FSRGMYSCCS AEAKPLTPDC DFRPLKMVIR PQTVTPTPKL
//
