ID A0A2U3YRY7_LEPWE Unreviewed; 570 AA.
AC A0A2U3YRY7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Zinc finger protein 583 isoform X1 {ECO:0000313|RefSeq:XP_006746490.1};
GN Name=ZNF583 {ECO:0000313|RefSeq:XP_006746490.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006746490.1};
RN [1] {ECO:0000313|RefSeq:XP_006746490.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006746490.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC {ECO:0000256|ARBA:ARBA00003767}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR RefSeq; XP_006746490.1; XM_006746427.2.
DR AlphaFoldDB; A0A2U3YRY7; -.
DR GeneID; 102732413; -.
DR KEGG; lww:102732413; -.
DR CTD; 147949; -.
DR OrthoDB; 3120634at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 12.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24404; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR24404:SF41; ZINC FINGER PROTEIN 835; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 7..78
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 213..240
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 241..268
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 269..296
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 297..324
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 325..352
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 353..380
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 381..408
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 409..436
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 437..464
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 465..492
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 493..520
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 521..548
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 549..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 570 AA; 66337 MW; A5E4D12B8CE6240C CRC64;
MSFQDLVTFG DVAVDFSQEE WEWLNPAQRN LYRKVMLENY RSLVSLGVSV SKPDVISLLE
QGKEPWMVKK EGTRGTCPDW EYTFKNNGFS SKQVIYEETS ELVKMGRSHL SYSLDCPSLR
EDYKSEDWLK NQLGSQEVHS RQLIITHKEM LTEDQSNEYT KSWQTFHQDA IFDIKKTFPT
KERVHKHEPQ KRSYRKKSVE MKHKKVYIQK KLLKCNECEK VFNQSSSLTL HQRIHTGEKP
YACVECGKTF SQSANLAQHK RIHTGEKPYE CKECRKAFSQ NAHLAQHQRV HTGERPYQCK
ECKKAFSQIA HLAQHQRVHT GERPFECIEC GKAFSNGSFL AQHQRIHTGE KPYVCNVCGK
AFSHRGYLIV HQRIHTGERP YECKECRKAF SQYAHLSQHQ RVHTGEKPYE CKVCRKAFSQ
IAYLDQHQRV HTGEKPYECI ECGKAFSNSS SLAQHQRSHT GEKPYMCKEC RKTFSQNAGL
AQHKRIHTGE KPYECNICGK AFSYSGSLTL HQRIHTGERP YECKDCRKSF RQRAHLAQHE
RIHTMESFLT PSSRSSPMSS QLPRPVGFIS
//
