ID A0A2U3YSB8_LEPWE Unreviewed; 280 AA.
AC A0A2U3YSB8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Forkhead box protein I2 {ECO:0000313|RefSeq:XP_006746620.1};
GN Name=FOXI2 {ECO:0000313|RefSeq:XP_006746620.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006746620.1};
RN [1] {ECO:0000313|RefSeq:XP_006746620.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006746620.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR RefSeq; XP_006746620.1; XM_006746557.1.
DR AlphaFoldDB; A0A2U3YSB8; -.
DR STRING; 9713.A0A2U3YSB8; -.
DR GeneID; 102730184; -.
DR KEGG; lww:102730184; -.
DR CTD; 399823; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd20053; FH_FOXI1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR PANTHER; PTHR11829:SF372; FORKHEAD BOX PROTEIN I2; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341}.
FT DOMAIN 65..159
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 65..159
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 150..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 280 AA; 29427 MW; B6BCA2F7CE4E1F41 CRC64;
MSFGAEPPGQ ARERLDMASY CDGSGVCPAP HSQARAAAPP AGYALGDLGA WLSLSGQQEL
LRLVRPPYSY SALIAMAIQS APLRKLTLSQ IYQYVAGNFP FYKRSKAGWQ NSIRHNLSLN
DCFKKVPREE DDPGKGNYWT LDPNCEKMFD NGNFRRKRKR RGEVGAAAPS GARSPGGAKA
PELEPLGAAA PDLQAPPSPP APDAAACFSS FTSAMGALAG GLGTFPAGLA GDFSFGRPTT
VAAQGPQAPG PAPGFGASHQ RAATGFRVGH FLYSREGTEV
//
