ID A0A2U3YSX3_LEPWE Unreviewed; 4069 AA.
AC A0A2U3YSX3;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Hydrocephalus-inducing protein homolog {ECO:0000313|RefSeq:XP_006746825.1};
GN Name=LOC102749204 {ECO:0000313|RefSeq:XP_006746825.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006746825.1};
RN [1] {ECO:0000313|RefSeq:XP_006746825.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006746825.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_006746825.1; XM_006746762.1.
DR STRING; 9713.A0A2U3YSX3; -.
DR GeneID; 102749204; -.
DR KEGG; lww:102749204; -.
DR OrthoDB; 49424at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 17.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR033305; Hydin-like.
DR InterPro; IPR033768; Hydin_ADK.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23053; DLEC1 DELETED IN LUNG AND ESOPHAGEAL CANCER 1; 1.
DR PANTHER; PTHR23053:SF0; HYDROCEPHALUS-INDUCING PROTEIN HOMOLOG; 1.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF17213; Hydin_ADK; 1.
DR Pfam; PF14874; PapD-like; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341}.
FT DOMAIN 1350..1548
FT /note="Hydin adenylate kinase-like"
FT /evidence="ECO:0000259|Pfam:PF17213"
FT DOMAIN 2252..2328
FT /note="Abnormal spindle-like microcephaly-associated
FT protein ASH"
FT /evidence="ECO:0000259|Pfam:PF15780"
FT REGION 316..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1239..1264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1276..1295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1467..1506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1658..1695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1796..1875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1961..2019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 820..851
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1248..1264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1480..1506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1658..1691
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1975..1990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1991..2017
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_006746825.1"
SQ SEQUENCE 4069 AA; 458288 MW; C8421462335D5914 CRC64;
EGDVWPNSSA EITVYFNPLE ARLYQQTVYC DISGKDFLYV EIVEDVPCIV PTLHMVNPEV
DFGHCFLKYP YEKTVQLVNH DDLPGCYTVL PQVYGDTPAV LLSSPMPCGV IPPHSTVHIP
LALETQVTGE YRSTVYISTF GSPDPPMVCR IKSIGEGPVI YVHPTQVDFG NIYVLKDSPR
ILNLSNQSFI PALFQARMAH TKSLWTIEPS KGMVPPETDV QLTLTANLND ILTFKDTVIL
DIENSNTYRI PVQASGVGST IVSDKPFAPE LNLGAHFSLD TYFYRFKLTN KGRRVQQLFW
MNEDFCPQDK LSKKGLAKKG LAKSQPQPQC SQESRAPPGP VFQLHPVRME LYPDQTIDVM
LEGYSATPRV RGHLLLQKPN TILEPDYQPL VMKNISTLPV NVLLSTSRPF FICESDKSPL
PLTPEPIKLE IDGEKNLLVK FDPSYRNDLN NWMAEEILAI KYMEHPQVDS LNLRGEVNYP
NLSFETMELD FGCILNDTEV IRYVTITNCS PLVVKFRWFF LVDNEENQIR FVSWPRKAYS
APLSQVESIP VISASASSPA VPAIESPEMD LNDFVKTVLT DEDVGCEERE YKEVQVPTVV
ISDGLKFNSA ETEKTDPNLS QVEFQEPPWI FEREEMLSIG IEEVFDILPL YGVLRPHSSH
QISFTFYGHC DITAQAKALC EVEGGPTYEI MLRGEASLVN YSFDTKDINY GLQLFDHVTE
KEITLRNTGK VGFEFKVLTD HLSSPDNLLP GAPLILPLSG FISSHQEQVL KVYYLPGVPE
VFQRSFQIQI AHLDPENITL RGEGIFPRIC LDLPRKLHGN KKYETFLNQA RKNLEKEHNK
YETLIDLETT EEMPEDESSE LSPQLQMEVE RLIVQGYAIE HQKTIIPDST DDFSYRSRRK
LAKVQLPEYI LDFGYIILGD VRTHIIKITN TSHFPVSFHA EKRILHDTGF STELDRVKNL
PYCETETFEV KFDPQGASLP VGNKEVILPI KVVGGPTIHI CLQAKVTIPT MTLSCGKVEF
ATIQCGQCLM ETVQFSNPLQ VPCEWFVHSH KPVNKLEKHM PKYLRRKLHA ELKPKTRIFE
IQPMSGVLGP GERSNVQVKF MPKEEKFYSQ TLVFQIAQSA QKLTLLAQGQ GLEPCLAFSP
SVLELGPLLP YAPGDEAEVV VKNPCSFPIE FYSLEFDQQY LLEEKILRTL KGYDPYNTLL
LPPRLPGEKL PPELYEYFKE MKRSKEEQMK AKYLESLVQE NEEEDGPSSD LGTSASTKRT
SLSLGISVTS NLEERHLPMM ESKTYPDEEE DEESLEKITF QTDKLQSIDS HSTEEVGEVE
NNPVSKAIAR HLGIDISAEG RMAKNRKGIA IVVHGTPLAG KTATAISMAK YYNAACLNID
SIVLEAISDG NNIPGIRARE LCIRAAIEQS IKEGEESAQE AASGQTAVGQ IRLSSETLGK
LTSESTLVTP EFKPTKTVRG SMMIAKSKTE SHGSGSQKQH HQHASETPQV SSSPLPTGPT
QCRLSVSPSV GGETGLMSCV LPEDLLTQIL AERIQLSDCF RGVVFDSLET LFAQNIAVAL
LCLLKAIGNR DHIYVVNMAQ EYTAMKAQEK AKKEQEEHKR REALEKEKER LQNMDEEEYD
AMTEEEKIMF NREVQQALRE RKKRELERLT REMREKKLQQ ELERQKEEDE LKRKVKRPKH
RPVKEEPLPK KSQTNRQVLT FSKLEVKMDA LERKVSVREH LNEKDDLSKR RKNQLGDIHM
LGFPLAQEQE DSEGDLLKDA DKHLAQKFKT YELTLKDIQN ILMNWDRKQG ILVHHTGAED
MPHEPDDQRQ VPSGGRRGRK DRERERAEKE RAEKERQERE KAERERLEKL RALEERSDGG
EGEGGEEDHH EGKKDLGVPF ITVQTPDFEG LSWKLALEND RLPKGDQILD ILGLGSSGPP
IPPPALFSII SYPLKRLPLT TTEILKHFVF VIPPSEELSL LEEKREGEAE TELSGTVGSG
KTQEEQTTSS KGSRQKPKEK ADQARDTQKD KRRMAFNRKG LSGGTAGVIA PLSDMDQNNF
AGQLSQEKFI RLNHFRWIVP ANGEVTLRIH FSSNELGNFD QTFNFEILGT HRQYQLYCRG
VCSYPYICQD PKVVFTQRKM DIKQNEVIFK KYVMRMEKFY FGPLLCGKSR DKYKSSLFPG
NMETLTILNN SPMVVEAFFC FQNDVKASTY FLEPVNMTLK PSEKQVLNVW AYPTAVGVFD
DCIVCCIKEN PEPAVFKLTC QGVRPELELD SRQLHFDRLL LHRKDSKVVL LRNVTPLPVA
WRITSLEHLG DDFTVSTMQG TIPPKAEYSL QVHFQPSKPV NIKKVIRLEV LDADNLIGVV
QIENILVFAE SYDVALDITF PKGAEGGLDF GIVKVMEEAK QPLQLKNRGK YEIMFSFSVD
SLGILATNVN SMISVQPKKG SLTSTEKPTT VQVLFRAKKE VKIEHQPVLR CQIIEPSITE
GGEIIASIPI KFSVNAVYSK YNISPSAIIN FGALICGTRK STTFTIENQG VTDFKYALYR
LTGESPIHQK KAVSHVRHAR SRESENFYKA SPSKAAKFSD AVQKEVNITN QVRFTHGMFT
VYPGFGSIPS GGTQVITVDC VADPVGRCEE FIAIDISDRD PRDQPAGIPY SLLAEACLPA
FVTDNNALIF EEHQICSSTT LLNILQTIEN GGLFVEDENK FIFCNVLVGH QAKARFKISN
VGKIACDVNI VVKPISNKLI ARITDIFDVE PNKMCVASRS HAFATVTFTP QTMQTYQCIF
EATLDGLPSN LTRNRSLVFD IVGEGNLPRV TIVRPVLCNQ YGNPLLLFRR LLLGQSEKLP
LILKNNGTIP AQLHVDLRDQ LGVFSLKGTL TTSYIYITEE NKPHAKAKKA HTASLVVPPG
NTAGFDVVFQ SQKVGRMAGT IHLSVINNQY EETIIHMVGE GYEDDITLGN IHGLVVSSSP
EAPEISEIIE ENTMEDLVAA ALVDHIQFGD CHIGNSYNVS FTITNHSQVN VIRFEWPPVA
TVSFSPQRIS SAEMVARLML RNSMEACMDE DRSQSSHPRV QTCVPQGREA RETVHIINKE
EQGFHFAFQD NSRYSEGFSN SLVIRPMEGW IPPLSRFPVD IFFTPKQEGD VNFNLICNVK
KKAHPLTLNV KAEGYTMNAE VKCKDRTGLI TLLTPKETNI INFYEVELNE CVQCELSFIN
TGKFNFSFQA ELSGPKALLQ YLEFSPIDGS VDVGQSAHAS LSFQPFKKCV LKGLELRIKI
SHGPTFLCSI SGCAVSPAVH FSFTSYNFGT CFIYQAGMPP YKQILVVTNK EETSMSLDCL
YTNTPYLEVN FRVDVIKPGK TLEIPITFYP RESIQYRELI PFEINGLSQQ IIEIKGKGTE
MKISVLDPSN RIVKLGAVLP GQVVKKTVSI MNTSHTHLTF SQSVLFSIPE LQEPKVITLI
PFHNITLKPK EVCKLEVIFA PKKRIPPFSE EVFMECMGLL RPLFLLSGCC QALEISLDQE
HLPFGPVVYQ TQATRRILML NTGDVGARFK WDVKKFEPHF SISPEEGYIT AGMEVSFEVT
YHPTEVGKES LYKNLLCFIQ GGNPLSLTLS GVCVGPPAVK EVVNFTCQVR SKHTQTILLS
NRTNQTWNLH PIFEGEHWEG PEFITLEPHQ QNKPYEITYR PRTMNLENRK HQGTLFFPLP
DGTGWLYMLH GVAELPKAVA NIFREVPCKT PYVELLPISN WLNKPQRFRV IVEMIKPEKP
DLSVTLKGLD YIDVLSGSKK DYKLNFFSHK EGLYSAKVIF RNEVTNEFLH YMVSFRVIPS
GIIKTIEMTS PVRQSTSASI KVENPLPYLV TFSTECRVPD ISLPSQFMVP ANSEGTFSFE
FQPLRAGETF GRLMLHNSDL GYYLYELSLK ATPALPEKPI HFQAILGSGQ SIFAKFTNYT
RQKTEYYCRT DCQDFHTEKI INAAPGAQGG TEVSVEVYFE PSHLGETKGI LMLSSITGGE
YIIPLFGVAL PPKPQGPFLI RAGYNIVIPF KNIFYHPVTF SFIVENPAFS VRAVDSVRPK
KINNITVSFE GNPSGSKTPI TSKLIVSCPP SEGNEAGVKW VYYLKGITP
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