ID A0A2U3YUI5_LEPWE Unreviewed; 354 AA.
AC A0A2U3YUI5;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Cellular communication network factor 6 {ECO:0000313|RefSeq:XP_006747386.1, ECO:0000313|RefSeq:XP_030874032.1};
GN Name=CCN6 {ECO:0000313|RefSeq:XP_006747386.1,
GN ECO:0000313|RefSeq:XP_030874032.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006747386.1};
RN [1] {ECO:0000313|RefSeq:XP_006747386.1, ECO:0000313|RefSeq:XP_030874032.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006747386.1,
RC ECO:0000313|RefSeq:XP_030874032.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the CCN family. {ECO:0000256|ARBA:ARBA00008125}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR RefSeq; XP_006747386.1; XM_006747323.2.
DR RefSeq; XP_030874032.1; XM_031018172.1.
DR GeneID; 102740037; -.
DR KEGG; lww:102740037; -.
DR CTD; 8838; -.
DR OrthoDB; 2970572at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR012395; IGFBP_CNN.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR043973; TSP1_CCN.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR11348:SF3; CELLULAR COMMUNICATION NETWORK FACTOR 6; 1.
DR PANTHER; PTHR11348; CONNECTIVE TISSUE GROWTH FACTOR-RELATED; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF19035; TSP1_CCN; 1.
DR PIRSF; PIRSF036495; IGFBP_rP_CNN; 1.
DR SMART; SM00041; CT; 1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00209; TSP1; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS50092; TSP1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..354
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041083073"
FT DOMAIN 44..117
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 268..342
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
SQ SEQUENCE 354 AA; 39235 MW; 5F1D9E1CA3CA75D3 CRC64;
MPGLLLSALL GAALAQFCCR AQGGGPLARA PEGRPGEEPE VQPRRQFCHW PCKCPRQKPS
CPPGVSLLRD GCGCCKICAK QPGDICNEAD LCDPHKGLYC DYSADRPRFE TGVCAHLIAV
GCEFNRVHYH NGQVFQPNPL FSCLCVSGAI GCTPLFIPKL ADSHCSGAKG RKKSNQSNCG
LGPFQQQLSA TYKTMPAYRN LPLVWKRKCL VQATKWTPCS RTCGMGISDR VTNENSNCEM
RKERRLCYIQ PCDSNISKRV KIPKGKTCQP TFQLLKAEKF VFSGCSSTQS YKPTFCGVCL
DKRCCVPNKS RMITIQFDCP NEGSFKWKML WITSCVCQRN CRDPGDVFSD LKIL
//
