ID A0A2U3YZM6_LEPWE Unreviewed; 421 AA.
AC A0A2U3YZM6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Ankyrin repeat and SOCS box protein 6 isoform X2 {ECO:0000313|RefSeq:XP_006749195.1};
GN Name=ASB6 {ECO:0000313|RefSeq:XP_006749195.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006749195.1};
RN [1] {ECO:0000313|RefSeq:XP_006749195.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006749195.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_006749195.1; XM_006749132.2.
DR AlphaFoldDB; A0A2U3YZM6; -.
DR STRING; 9713.A0A2U3YZM6; -.
DR GeneID; 102737345; -.
DR KEGG; lww:102737345; -.
DR CTD; 140459; -.
DR OrthoDB; 5352456at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03725; SOCS_ASB6; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037327; ASB6_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24132; ANKYRIN REPEAT AND SOCS BOX PROTEIN 6; 1.
DR PANTHER; PTHR24132:SF24; ANKYRIN REPEAT AND SOCS BOX PROTEIN 6; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341}.
FT REPEAT 102..134
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 136..169
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 360..415
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 421 AA; 47125 MW; AC3CF6153568F2B7 CRC64;
MPFLHGFRRI IFEYQPLVDA ILGSLGIQDP ERQEPLDGPS YVASEESRIL VLTELLERKA
HSPFYQEGVS NALLKMAELG LTRAADVLLR HGANLNFEDP VTYYTALHIA VLRNQPDMVE
LLVRHGADIN RRDRIHESSP LDLASEEPER LPCLQRLLDL GADVNAADKH GKTALLHALA
SSDGVQIYNT ENIRLLLEGG ADVKATTKDG DTVFTCIIFL LGETVGGDKE EAQMISRFCF
QVTQLLLAHG ADPSECPAHE SLTHICLKSF KLHFPLLRFL LESGAAYNCS LHGASCWSGF
HIIFERLCSH TGCAEDESHM DLLRKAETVL DLMVTNSQKL QLPENFDIHP VGSLAEKIQA
LHCSLRQLES YPPSLKHLCR VYIRLHLQPW PVDVKVKALP LPDRLKWYLL SEHSGTVEED
I
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