ID A0A2U3Z2J3_LEPWE Unreviewed; 239 AA.
AC A0A2U3Z2J3;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2021, sequence version 2.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Acid-sensing ion channel 2 {ECO:0000313|RefSeq:XP_006750227.2};
GN Name=LOC102742650 {ECO:0000313|RefSeq:XP_006750227.2};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006750227.2};
RN [1] {ECO:0000313|RefSeq:XP_006750227.2}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006750227.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR RefSeq; XP_006750227.2; XM_006750164.2.
DR AlphaFoldDB; A0A2U3Z2J3; -.
DR STRING; 9713.A0A2U3Z2J3; -.
DR KEGG; lww:102742650; -.
DR OrthoDB; 3415680at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR020903; ENaC_CS.
DR PANTHER; PTHR11690:SF128; ACID-SENSING ION CHANNEL 2; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022480};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679}; Taste {ECO:0000256|ARBA:ARBA00022480};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|RuleBase:RU000679}.
SQ SEQUENCE 239 AA; 27019 MW; F0910DC7205B34E4 CRC64;
MSSLRSLSFY SEVTHVLLSL FSLLQVFTKY GKCYMFNSGE DGKPLLTTVK GGTGNGLEIM
LDIQQDEYLP IWGETEETTF EAGVKVQIHS QSEPPFIQEL GFGVAPGFQT FVATQEQRLT
YLPPPWGECR SSEMGLDFFP VYSITACRID CETRYIVENC NCRMVHMPGD APFCTPEQHK
ECAEPALGLL AEKDSNYCLC RTPCNLTRYN KELSMVKIPS KTSAKYLEKK FNKSEKYIS
//
