ID A0A2U3Z482_LEPWE Unreviewed; 213 AA.
AC A0A2U3Z482;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Bcl-2-related ovarian killer protein isoform X1 {ECO:0000313|RefSeq:XP_006750815.1};
GN Name=BOK {ECO:0000313|RefSeq:XP_006750815.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006750815.1};
RN [1] {ECO:0000313|RefSeq:XP_006750815.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006750815.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Bcl-2 family.
CC {ECO:0000256|ARBA:ARBA00009458}.
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DR RefSeq; XP_006750815.1; XM_006750752.2.
DR AlphaFoldDB; A0A2U3Z482; -.
DR STRING; 9713.A0A2U3Z482; -.
DR GeneID; 102737864; -.
DR KEGG; lww:102737864; -.
DR CTD; 666; -.
DR OrthoDB; 2909137at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd06845; Bcl-2_like; 1.
DR Gene3D; 1.10.437.10; Blc2-like; 1.
DR InterPro; IPR036834; Bcl-2-like_sf.
DR InterPro; IPR046371; Bcl-2_BH1-3.
DR InterPro; IPR026298; Bcl-2_fam.
DR InterPro; IPR002475; Bcl2-like.
DR PANTHER; PTHR11256; BCL-2 RELATED; 1.
DR PANTHER; PTHR11256:SF48; BCL-2-RELATED OVARIAN KILLER PROTEIN; 1.
DR Pfam; PF00452; Bcl-2; 1.
DR PRINTS; PR01862; BCL2FAMILY.
DR SMART; SM00337; BCL; 1.
DR SUPFAM; SSF56854; Bcl-2 inhibitors of programmed cell death; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Reference proteome {ECO:0000313|Proteomes:UP000245341}.
FT DOMAIN 71..172
FT /note="Bcl-2 Bcl-2 homology region 1-3"
FT /evidence="ECO:0000259|SMART:SM00337"
SQ SEQUENCE 213 AA; 23307 MW; 24BE0455227D5092 CRC64;
MEVLRRSSVF AAEIMDAFDR SPTDKELVAQ AKALGREFVH ARLLRAGLAW SAPERAAPAP
GGRLAEVCAV LLRLGDELEL IRPSVYRNVA RQLNISLQSE TVVTDAFLAV ASQIFSGGIT
WGKVVSLYSV AAGLAVDCVR QAQPAMVHAL VDCLGEFVRK TLAPWLRRRG GWTDVLKCVV
STEPGFRSHW LVAALCSFGR FLKAAFFVLL PER
//
