ID   A0A2U3Z4M8_LEPWE        Unreviewed;       796 AA.
AC   A0A2U3Z4M8;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE            EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN   Name=LOC102748436 {ECO:0000313|RefSeq:XP_006750698.1};
OS   Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC   Leptonychotes.
OX   NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006750698.1};
RN   [1] {ECO:0000313|RefSeq:XP_006750698.1}
RP   IDENTIFICATION.
RC   TISSUE=Liver {ECO:0000313|RefSeq:XP_006750698.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361199};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR   RefSeq; XP_006750698.1; XM_006750635.2.
DR   AlphaFoldDB; A0A2U3Z4M8; -.
DR   STRING; 9713.A0A2U3Z4M8; -.
DR   GeneID; 102748436; -.
DR   KEGG; lww:102748436; -.
DR   OrthoDB; 5474711at2759; -.
DR   Proteomes; UP000245341; Unplaced.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.40.1360; -; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 2.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR048534; Man2a1-like_dom.
DR   PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR   PANTHER; PTHR11607:SF3; LYSOSOMAL ALPHA-MANNOSIDASE; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   Pfam; PF21260; Laman-like_dom; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW   Hydrolase {ECO:0000256|RuleBase:RU361199};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361199};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT   DOMAIN          177..256
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   796 AA;  89582 MW;  97847C16A5B1CA7B CRC64;
     MGFDGFFFGR LDYQDKGVRK KKQEMEQVWR ASASLEPPVA DLFTSVLPNI YNPPEKLCWD
     TLCADKPFVE DPRSPEYNAK ELVDYFLQLA TAQGQNYRTN HTIMTMGSDF QYENANMWFK
     NLDRLIELVN AQQQANGSRV NVLYSTPACY LWELNKANLT WSVKQDDFFP YADGPHKFWT
     GYFSSRPALK RYERLSYNFL QVCNQLEALA GPAANVGPYG SGDSAPLNEA MAVLQHHDAV
     SGTSRQHVAN DYARQLAAGW GPCEVLLSNA LARLSGSKED FMYCRNLNIS VCPLSQTAKS
     FQVTIYNPLG RKVDWMVRLP VSDHIFDVRD PNGTIVPSDV VRLPSSDSSD LLFSASVPAL
     GFSVYSVTQV PGRSPHAHNR QPRSQKSWTH GLAIQNEYLQ ARFDPDTGLL VELENLDQNL
     LLPVRQAFYW YNASVGDNLS TQVSGAYIFR PNRQEPLIVS HWAQTHVVKT PLVQEVHQNF
     SAWCSQVIRL YPGQRHLELE WTVGPIPVGD GWGKEIISRF DTVLETKGLF YTDSNGREIL
     ERRRDYRPTW KLNQTEPVAG NYYPVNSRIY IRDGKMQLTV LTDRSQGGSS LKDGSMELMV
     HRRLLKDDGR GVGEPLLEEG LGLWVRGRHL VLLDKAPTAA TRHRLQAEKE LLAPQVVLAP
     GGGAPYHPGV APRKQFSGLR RELPPSVHLL TLARWDRTTL LLRLEHQFAV GEGSGNLSSP
     VTLDLRDLFS AFTITYLQET TLAANQLRAS ASRLKWTPAT GPTAQPSPSR LDPAAITLQP
     MEIRTFLALV QWKEHG
//