ID A0A2U3Z5Z5_LEPWE Unreviewed; 153 AA.
AC A0A2U3Z5Z5;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Granulocyte-macrophage colony-stimulating factor {ECO:0000256|ARBA:ARBA00018697};
DE AltName: Full=Colony-stimulating factor {ECO:0000256|ARBA:ARBA00029601};
GN Name=CSF2 {ECO:0000313|RefSeq:XP_006751153.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006751153.1};
RN [1] {ECO:0000313|RefSeq:XP_006751153.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006751153.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cytokine that stimulates the growth and differentiation of
CC hematopoietic precursor cells from various lineages, including
CC granulocytes, macrophages, eosinophils and erythrocytes.
CC {ECO:0000256|ARBA:ARBA00003164}.
CC -!- SUBUNIT: Monomer. The signaling GM-CSF receptor complex is a dodecamer
CC of two head-to-head hexamers of two alpha, two beta, and two ligand
CC subunits. {ECO:0000256|ARBA:ARBA00025874}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the GM-CSF family.
CC {ECO:0000256|ARBA:ARBA00009378}.
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DR RefSeq; XP_006751153.1; XM_006751090.2.
DR AlphaFoldDB; A0A2U3Z5Z5; -.
DR STRING; 9713.A0A2U3Z5Z5; -.
DR GeneID; 102726081; -.
DR KEGG; lww:102726081; -.
DR CTD; 1437; -.
DR OrthoDB; 5263930at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005129; F:granulocyte macrophage colony-stimulating factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00040; CSF2; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000773; GM_colony-stim-fac.
DR PANTHER; PTHR10059:SF0; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; 1.
DR PANTHER; PTHR10059; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR GM-CSF; 1.
DR Pfam; PF01109; GM_CSF; 1.
DR PRINTS; PR00693; GMCSFACTOR.
DR SMART; SM00040; CSF2; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00702; GM_CSF; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000245341};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..153
FT /note="Granulocyte-macrophage colony-stimulating factor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015495096"
SQ SEQUENCE 153 AA; 17002 MW; 5C943AFA7A1D82E9 CRC64;
MWLQNLLFLG TVVCSISAPT SSPSPVTRPS QHVDAIQEAL SLLNKSRNET AVMNEVVKVV
SGMFDHQEPT CLQTRLRLYT EGLQGSLSSL KQPLTLMANH YKQHCPPTPE TPCATETITL
KNFKGNLKEF LFNIPFDCWQ PETTEASAAR SQP
//
