ID A0A2U3Z7T0_LEPWE Unreviewed; 659 AA.
AC A0A2U3Z7T0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=FERM domain-containing protein 4B {ECO:0000313|RefSeq:XP_006752034.1};
GN Name=LOC102727088 {ECO:0000313|RefSeq:XP_006752034.1};
OS Leptonychotes weddellii (Weddell seal) (Otaria weddellii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Leptonychotes.
OX NCBI_TaxID=9713 {ECO:0000313|Proteomes:UP000245341, ECO:0000313|RefSeq:XP_006752034.1};
RN [1] {ECO:0000313|RefSeq:XP_006752034.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_006752034.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_006752034.1; XM_006751971.1.
DR AlphaFoldDB; A0A2U3Z7T0; -.
DR STRING; 9713.A0A2U3Z7T0; -.
DR GeneID; 102727088; -.
DR KEGG; lww:102727088; -.
DR OrthoDB; 3400049at2759; -.
DR Proteomes; UP000245341; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0090162; P:establishment of epithelial cell polarity; IEA:InterPro.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR021774; CUPID.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR047176; FRMD4A/B.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR46079; FERM DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR46079:SF1; FERM DOMAIN-CONTAINING PROTEIN 4B; 1.
DR Pfam; PF11819; CUPID; 1.
DR Pfam; PF09380; FERM_C; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000245341}.
FT DOMAIN 1..69
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 348..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_006752034.1"
FT NON_TER 659
FT /evidence="ECO:0000313|RefSeq:XP_006752034.1"
SQ SEQUENCE 659 AA; 74584 MW; 14E5217E9560E3B9 CRC64;
LFQWKQLENL YFREKKFAVE VHDPRRISVS RRTFGQSGLF VQTWYANPSL IKSIWVMAIS
QHQFYLDRKQ SKAKIPSARS LDDIAMDLTE TGTPRVSKMV TLEAKTQFIM ASNGSLISSG
SQDSEVSEEQ KREKILELKK KEKLLQEKLL KKVEELKKIC LREAELTGKM PKEYPLSVGE
KPPQVRRRVG TAFKLDDNLL PSEQDPALQE LESNFLIQQK LVEAAKKLAN EPDLCKTVKK
KRKQDYTDAV KKLQEIENAI NEYRIRCGKK PSQKATVILP EDIIPSESSS LSDTTTYDDS
NDTFALAGQR PSSVPHSPRI LPPKSLGIER IHFRKSSVNE QFVETRQSRE MLSTHGSPCK
TLERRPLGGQ SMPTTPVLTR NAYSTSHLEP ESSAQHCRQR SGSLESQSHL LSEMDNDKPF
FSLSKSQRSS STEILDDGSS YTSQSSTEYY CVTPVAGPYY TTQTLDTRAR GRRRSKKQSV
STSNSGSMPN LAQKDSLRNG VYTKSQEQPS SGYYIAGYTP YPECDLYYSG GYVYENDTEG
QYSVNPSYRA SAHYGYERQR DYSRSFHEDE VDRVPHNPYA TLRLPRKAAA KSEHITKNIH
KALVAEHLRG WYQRASGQKD QGHSPQTSFD SDRGSQRCLG FAGLQVPCSP SSRTSSYSS
//
