ID A0A2U4A1B8_TURTR Unreviewed; 1003 AA.
AC A0A2U4A1B8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=KN motif and ankyrin repeat domain-containing protein 4 {ECO:0000313|RefSeq:XP_019774793.2};
GN Name=KANK4 {ECO:0000313|RefSeq:XP_019774793.2};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019774793.2};
RN [1] {ECO:0000313|RefSeq:XP_019774793.2}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019774793.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_019774793.2; XM_019919234.2.
DR AlphaFoldDB; A0A2U4A1B8; -.
DR STRING; 9739.ENSTTRP00000008867; -.
DR InParanoid; A0A2U4A1B8; -.
DR OrthoDB; 123304at2759; -.
DR Proteomes; UP000245320; Chromosome 1.
DR GO; GO:0030837; P:negative regulation of actin filament polymerization; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047184; KANK1-4.
DR InterPro; IPR021939; KN_motif.
DR PANTHER; PTHR24168; KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24168:SF24; KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF12075; KN_motif; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 831..856
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 903..935
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 936..961
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 70..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..298
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..551
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..720
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1003 AA; 107348 MW; AC7ACFEC3803A397 CRC64;
MEKTDAKDQS SQGDEEKDPP KSHPYSVETP YGFHLDLDFL KYVDDIEKGN TIKRIPIHRR
AKQAKFSTLP RNFSLPDSGA RPHAALSHPN WPPVVPSKVS LGTEARAQPL PLGDHPQAAG
GSEASYHRKA LLTETARQLE AEVASGSGRP QLLRASSMPA TLLQNRASED PSLNSGPPTP
PALPPLQGEG GVCDGAFGPA EGFAGFSNSA QGAAAQLEVR ESGNLVPGIP ELILKGPEPP
EGEEAAANHL PFSSPPFSSL VVLEDAEDQQ ESRQAEVAVT TPGSPTPSPP PLPSPVPENE
LPLEEIELNI IEIPPPPPVE VDVRSIGIRV TEESLGLTSV DPGSISSLKQ QLSGLEGELS
GRTEELAQVR AALQRQEEEI KARGQRIREL ECTLAQLTGK LSHENTKDAQ GQTDAMTNTD
PLHGLLTRES CDKSIGVNLM GSTRSESWGA WGKGNGVLWR QESHKWGDRG PAEFVSPSQL
SLPQGSKMVL TPSLHSCLST ELRIEEGRSD QEGGHQVGAE GPVRGARGSP RSSERKAPPA
GRKEAGSELP GKERPGRPPS SPTTDATIGQ YVKKIQELLQ EQWSCLEHGY PELAHAIKQP
ASKLSSIQSQ LQSSLNLLLS AYSAHAAPQR EPPGPSSSPP TEISPSTSLK SIMKKKDYGF
RAGGNGTKKN LQFVGVNGGY ETTSSEETSS EDTSPEDLSD SEAEKKCDGP ESRRGKDAHL
SYKAGQGIPE GTRDTDQQSG PGEELPHPKA ERYKPSEEFL NACRALSQHL PETGTTTDQL
LKQSLNTISQ EWFRVSSRKS SSPAVVATYL RGVQPHSPHL LKLLVNLADG NGNTALHYSV
SHSSFSIVRL LLETGVCNVD HQNKAGYTAV MITPLASAET DEDMAVVWKL LREGDVNIQA
TQGGQTALML GVSHDREDMV QALLSCQADV NLQDHDGSSA LMLACRHGNV DMVRLLLAHP
ACDSSLTDKA GRTALSIVLK SPAHVEIAGL LRAHAKQGRS LGP
//
