ID A0A2U4A1K9_TURTR Unreviewed; 677 AA.
AC A0A2U4A1K9;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Zinc finger CCCH domain-containing protein 14 {ECO:0000256|ARBA:ARBA00015071, ECO:0000256|RuleBase:RU369058};
GN Name=ZC3H14 {ECO:0000313|RefSeq:XP_019774882.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019774882.1};
RN [1] {ECO:0000313|RefSeq:XP_019774882.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019774882.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in poly(A) tail length control in neuronal cells.
CC Binds the polyadenosine RNA oligonucleotides.
CC {ECO:0000256|ARBA:ARBA00003177, ECO:0000256|RuleBase:RU369058}.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|RuleBase:RU369058}.
CC Note=Colocalizes with poly(A) RNA in nuclear speckles.
CC {ECO:0000256|RuleBase:RU369058}.
CC -!- SIMILARITY: Belongs to the ZC3H14 family.
CC {ECO:0000256|ARBA:ARBA00008423, ECO:0000256|RuleBase:RU369058}.
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DR RefSeq; XP_019774882.1; XM_019919323.2.
DR AlphaFoldDB; A0A2U4A1K9; -.
DR GeneID; 101327980; -.
DR OrthoDB; 5400456at2759; -.
DR Proteomes; UP000245320; Chromosome 2.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008143; F:poly(A) binding; IEA:UniProtKB-UniRule.
DR GO; GO:1900364; P:negative regulation of mRNA polyadenylation; IEA:InterPro.
DR GO; GO:0043488; P:regulation of mRNA stability; IEA:UniProtKB-UniRule.
DR Gene3D; 4.10.1000.30; -; 1.
DR Gene3D; 4.10.1000.40; -; 1.
DR InterPro; IPR040366; Nab2/ZC3H14.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR14738; ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14; 1.
DR PANTHER; PTHR14738:SF29; ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14; 1.
DR Pfam; PF14608; zf-CCCH_2; 5.
DR SMART; SM00356; ZnF_C3H1; 3.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU369058};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU369058};
KW RNA-binding {ECO:0000256|RuleBase:RU369058};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 536..561
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT ZN_FING 536..561
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 677 AA; 76063 MW; B50E83B2836343BA CRC64;
MLQRSRLHGV LDKLRSVTTD PSSLKSSDTN IFDSNVPSNK SSFSRGDERR HEAAVPPLAV
SSTRPEKRES RVSTSSQEQK ATNVRQTYDD GAATRLMSTV KPLREPAPSE DVIDIKPEPD
DLIDEDLNFV QENPLSQKKP TVTLTYGSSR PSIEIYRPPA SRNADSGAHL NRLQFQQQQN
SIHAAKQLDI QTSRIYETGR LCEPEVLNSL EETYSPFFRN SSEKMSIEEE NFRKRKLPVV
SSVVKVKKFN HDGEEEEEDD DCGSRTGSIS SSVSVPAKPE RRPSLPPSKQ ANKNLILKAI
SEAQESVTKT TNYSAVSQKQ TLPVAPRTRT SQEELLAEMV QGQSRAPRMS SPIKEEETKG
DNIDKSQGTQ QRQLLSRLQI DPVMAETLQI SQDYYDMESM VHADTRSFIL KKPKLSEEIV
VAPNQESGMK TADTLRVLSG HLMQTRDLVQ PDKPASPKFI VTLDGVPSPP GYMSDQEEDM
SFEGMRPAHH TAASHEGLAG LLHPQQLHLL SRQLEDPDGS FTNAEMSELS VAQKPEKLLE
RCKYWPACKN GDECAYHHPV SPCKAFPNCK FAEKCLFVHP NCKYDAKCTK PECPFTHMSR
RIPVLPPKPA VTTPAPPSSS QLCRYFPACK KMECPFYHPK HCRFNTQCTR PDCTFYHPTI
TVPPRHALKW IRPQTSE
//
