ID A0A2U4A1Y9_TURTR Unreviewed; 484 AA.
AC A0A2U4A1Y9;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Interleukin-6 receptor subunit alpha isoform X1 {ECO:0000313|RefSeq:XP_019775011.1};
GN Name=IL6R {ECO:0000313|RefSeq:XP_019775011.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019775011.1};
RN [1] {ECO:0000313|RefSeq:XP_019775011.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019775011.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 3
CC subfamily. {ECO:0000256|ARBA:ARBA00010890}.
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DR RefSeq; XP_019775011.1; XM_019919452.2.
DR AlphaFoldDB; A0A2U4A1Y9; -.
DR GeneID; 101335864; -.
DR InParanoid; A0A2U4A1Y9; -.
DR OrthoDB; 5363020at2759; -.
DR Proteomes; UP000245320; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003530; Hematopoietin_rcpt_L_F3_CS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR015321; TypeI_recpt_CBD.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF98; INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF09240; IL6Ra-bind; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS01354; HEMATOPO_REC_L_F3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_019775011.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..484
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015600730"
FT TRANSMEM 383..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..96
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 234..332
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 330..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 484 AA; 52903 MW; 78B461961D41D7C4 CRC64;
MLAVRCALLT ALLATPGTAL APGGCPALEV PNDVLTSLPG ASVTLTCPGG EAGDNATVHW
VLRNQVTGSR QGRWAGVGRR LLLRSVLLSD SGNYSCYEDG RPAGSVRLLV DVPPEEPQLS
CFRRSPLSNV GCEWSPRSPP SPTTKAVLLV RKFAKSPGPV REPERTTSLM PRPVKDFQEP
CQYSPESQQF SCQLAVPEGD NSLYVVSLCV SNSAGSQSSR PQTFEGYGIL QPDPPVNVTV
TAVDRNPRWL SVTWQDPPSW NSYFYRLQFE LRYRAERSKT FTMWMVKELQ YHCIIHDAWS
GMKHVVQLRA QEEFGHGLWS EWSQEVTGVP WTESKSSPAE TELPPSAQAP TTNEDNENIF
SKDSANATSL PVQDSTSVPL PTFLVAGGSL AFGTLLCIGI VLRFKKTGKL QALKEGKTSV
HPPYSLGQLV PERPKPTPVL VPLISPPVSP SSLGSDNTSR TSRPDASGPQ RPYDVSNRDY
FFPR
//
