ID A0A2U4A452_TURTR Unreviewed; 2683 AA.
AC A0A2U4A452;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Probable helicase senataxin isoform X1 {ECO:0000313|RefSeq:XP_019775767.1};
GN Name=SETX {ECO:0000313|RefSeq:XP_019775767.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019775767.1};
RN [1] {ECO:0000313|RefSeq:XP_019775767.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019775767.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_019775767.1; XM_019920208.2.
DR STRING; 9739.ENSTTRP00000011529; -.
DR GeneID; 101335263; -.
DR InParanoid; A0A2U4A452; -.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000245320; Chromosome 6.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR CDD; cd18042; DEXXQc_SETX; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF525; HELICASE SENATAXIN-RELATED; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|RefSeq:XP_019775767.1};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000313|RefSeq:XP_019775767.1};
KW Hydrolase {ECO:0000313|RefSeq:XP_019775767.1};
KW Nucleotide-binding {ECO:0000313|RefSeq:XP_019775767.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320}.
FT DOMAIN 1940..2221
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 2229..2428
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 604..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1171..1265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1354..1400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2510..2541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2562..2683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2081..2140
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 604..621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..640
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1205..1229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1354..1375
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1376..1397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2510..2526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2626..2646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2660..2683
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2683 AA; 302456 MW; C9E6F2F548C2932D CRC64;
MSTCCWCTPG GISTIDFLQH YASETHSSEF QKADEDLCYC LECVAEYHKA RDELPSLHKV
LWELETSRLI NHFEKAMKAE IGDDDELYIV DDNGEAQLFD FTGQDFENKL RVPLLEILKY
PYLLLHERVN ELCVEALCRM EQANCSFQVF DKHPGIYLFL VHPNEMVRRW AILTARNLGK
VDRDDYYDLQ EVLTCLFKVI ELGLLESPDI YTSSVLETGK LILLPSHMYD AANYKNYWLG
ICMLLTILEE QAMDSLLLGS NKQNDFMQSI LHTMERQSDD DSVDPFWPAL HCFMVILDRL
GSKVWGQLID PIEAFQTIIN NVSYNKEIQN IRNSSMRSKF KPESCLDDTV TCSQIVYNYN
PEKTKKDSGW RSAICPDYCP NMYEEMETLA NVLQSDIGQD MRVHNSTFLW FIPFVQSLMD
LKDLGVAYIV EVIHHLHSEV KDVLNQTDAV CDTVTEFFLL ILVSVIELHR NKKCLHLLWV
SSQQWVEAIV KCAKLPTAAF ARSSEKSSGN CSKGTMISSL SLHSVPSNSV QRACVQLIRS
LLKEGIEPGQ QALRKRFLDK LNLFLRGNSS LGCQLTSQET HELQTCLKQI IRNIKFKVPQ
CSTSVDLTSP CKTPPASYNK EESEQTGKKS KKDRHCLENS SPTFSKEPMK ADACQVQESI
FSKADNAIEE DNERTYIKDL KLKDHLSAEL CLKPSSKRLV NERARGQVKI STGKHKSVKE
NSSYTPQNCT SRNGPEKVFD RGIITSTHLL TDSSNDSLEK VSTSNEDFSL KGDALGKTSK
AKTKAHKDEI CAKLSHVVKK QHRKSITLEE NLTVSSIESF YSKDTGGQKG DGFIYNLSLG
PNGILDDKNG EQKSENSLLL KKKQVKEEEL GILSTRELSC QILECHVGNK DLVSFTEMTN
IFVEKTPPFK DPVTGLESRD MEIIKSTAQF SSDLREQVLS SPKSDTLTDS QVDRDLHKLS
LVAQASVIKF PSDSTQKSLS QLQRKVKDDR RCFTANQNSV RETCCEQVII ISDSDEDDDD
DERIVGFKKR IKQDKTCIEK ECPEQHASIA NTNVEQKVIR EENTGSPLQF EESDSQFFEF
ESPCEVFSVW QDQKPDNKNS VQENEENSCL THVGDTTNDW GYGTDYVPEE VIKKAAEDIE
EHAEPHSSSI SVEEFCEIEV KKPKRKRYQK AAMAEAPLRP SSPVKSEDQS DILNERDVTE
NDFKSIDVRS TTPSSSVQRT TTVSLKKSPP KLRNCSKRVS RVSLSKTPKK TRSDTKTGQS
KTSNILSCRT SPAIVLPKKF RQRPEPTSTV EKLGLKKVAR RAFDLSQPSL ERLADLRHHG
RTVGAIDTRK KTKLISPQTL SVRNNEKLLT SQDRQLRRQL RPKSQRNRKR CFDYQSTDTT
RAGPQGAQNS DKFVPESDTS DYSYKGGVEV TAKSKETELI KCVSSETEPV KAEYVSQVAD
DPCLLNQGTS VVLHGEIPTN EVVVSTSGDP LGGGDLTVHH LAVAALREGD PESSNDIEED
NIFLTQCDPE DMDLCSQMEK ENDKLVEVVH GKDTVQVEEG YVSRPQLESS SSTKCKYKDC
VETLKNQGEY CSKHSEAKAA DEAIFRKPGL PLSASKPSRP PTAKIFSSSS TSRIAGLSKS
LENTAALLPT LKNKSSGVQS VLKVPPVSLV SKKPVAEVKG LCNVLHSHAP NNSNRQGYKV
PYCENRSFSA SPPVNVLLSA QSISDTFVKE VLKWKYEMFV NFDQCGPPST LCQSISRPVP
VRFQDGGDYF NVFFPLMMLN TFETVAQEWI SSPNKEKFHW LHLRKFPSEY KKYWEFVVYL
EECELAKQLH PKENDLVFLV PERLNGEEED IERNRMQDPY EYYCGYVHKF RRTSVMHNGK
SECSVSIQTQ HNLPVNLNEF VKCLVISSLV TTQRKLKAMS LLSGRNQLAR AVLNPNPMDF
CTKDLLTAAS EKIIAHLKDF NEDQKKAIET AYAMVRHSPA VAKICLIHGP PGTGKSKTIV
GLLYRLLTER RGLSDENSNA KIKRNRVLVC APSNAAVDEL MKKIILQFKG KCKDKKNPLG
NCGDINLLRL GPEKSINAEV LKFSLDSQVN HRMKKELPSH IQEMHRRKEF LDHQLDELSR
QRALCRGGRE LQRQELDEKI ARVSKERQEL ASKVKEVQGR PQKTQNTIIL ESHIICCTLS
TSGGLLLEAA FRGQGGVPFS CVIVDEAGQS CEVETLTPLI HRCNKLILVG DPKQLPPTVI
SVKAQEYGYD QSMMARFYKL LEENVKHNMI GRLPVLQLTV QYRMHPDICL FPSNYVYNRN
LKTNRITEAI RCSSDWPFQP YLVFDVGDGS EKRDNDSYVN VQEIKLVMEL VKLMKDKKRD
FTYRNVGIIT HYKAQKMMIQ KDLDKEFDRK GPAEVDTVDG FQGRQKDCVI VTCVRANAMQ
GSIGFLASLQ RLNVTITRAK YSLFILGHLR TLMENCHWNQ LIQDAQKRGA IVKTWDKNYR
QDAVKILKLK PVLQRSLTHP PAIAPEVSRP QGGVPSNKLD SEFAKMSIAS SLYPSPSDSK
EATVTVTAND PERPPIQDWL RDPRLLRRMG LGCEAKGKCL SELQPSSPQY PGAAPLSGEP
GSPGRHQDPT SIGQQPPAKG AAVNNHRPHA QCDPPAASTD ASTSKRKCAQ EGEAVSHRRE
TRAFPEGDQE TCGSLSHHTK RNSGWDERGL EEEDSSLKKR KLS
//
