ID A0A2U4A7H3_TURTR Unreviewed; 884 AA.
AC A0A2U4A7H3;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 2.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Sorting nexin-25 isoform X9 {ECO:0000313|RefSeq:XP_019776947.2};
GN Name=SNX25 {ECO:0000313|RefSeq:XP_019776947.2};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019776947.2};
RN [1] {ECO:0000313|RefSeq:XP_019776947.2}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019776947.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR RefSeq; XP_019776947.2; XM_019921388.2.
DR AlphaFoldDB; A0A2U4A7H3; -.
DR Proteomes; UP000245320; Chromosome 21.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06878; PX_SNX25; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037899; SNX25_PX.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF29; SORTING NEXIN-25; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 141..307
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 430..544
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 552..672
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 884 AA; 100872 MW; EE49E37E7D1ED82A CRC64;
MHPEATDSSG AGLTEAPGER RPDSREDAAA PGGPGGGSWR APVAVAALAA VPLCFLGPGC
WEAGSAGPGT VLLRLSLYLG CAAAAFLLGT LFSLVCRSPR APPPDFAAAW RRLAAAARRP
PESPVCGNSH ESVQSRRVVI SHNMDKALKE VFDYSYRDYI LSWYGSLSRD EGQLYHLLSE
DFWEVVRRLR HRLSRVDMVR VVCSDVVRAL LAHFCDLKAA DARHEEQPRP FVLHAFLRNS
DDEVRFLQTC SRVLVFCLLP SKDVQSLSLR IMLAEILTAK VLKPVVELLS NPDYINQMLL
AQLEHREQVN EHHKRAYTYA PSYEEFIKLI NSNSDVEFLK QLRYQIVVEI IQATTISSFP
QLKRHKGKET AAMKADLLRA RNMKRYINQL TVAKKQCEKR IRILGGPAYD QQEDGPLDEG
EGPQSQKILQ FEDILANASY REHFRTYMER MDKRALISFW ESVEYLKNAH KNEIPQLVGE
IYQNFFVESK EISVEKSLYK EIQQCLVGNK GIEVFCKIQG DVYEMLKDRY YPSFIVSDLY
EKLMIKEEEK HVSQLISNKD EMVTEENGEQ MPCYFVMVSL QEVGGVETKN WTVPRRLSEF
QNLHRKLSEC FPSLKKVQLP SLSKLPFKSV DQKFMEKSKN QLNKFLQNLL SDERLCQSEA
LYAFLSPSPD YLKVIDVQGK KSTFSLSSFL ERLPRDFFSH QEEEAEEDSD LSDSGDDVDG
RKDSLAEPCF MLIGEIFELR GMFKWVRRTL IALVQVTFGR TINKQLRDAV DWALSEQMVV
YYIGALRDAL WPGGNLAPPN TIPSEEQSQE TKRRAQQKLL ENIPDMLQSL VGQQNARHGI
IKIFNALQET RANKHLLYVL MELLLIELCP ELRTHLDELK ACQV
//
